Is there a link between neutrophil-lymphocyte ratio and microvascular complications in geriatric diabetic patients?
Is there a link between neutrophil-lymphocyte ratio and microvascular complications in geriatric diabetic patients?
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DOI：
10.3275/8894
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发表时间：
2013-09-01
影响因子：
5.4
通讯作者：
Ariogul, S.
中科院分区：
文献类型：
--
作者：
Ozturk, Z. A.;Kuyumcu, M. E.;Ariogul, S.
背景：慢性炎症通过免疫炎症机制在 2 型糖尿病 (T2DM) 的发生和进展中发挥重要作用。中性粒细胞与淋巴细胞比率（NLR）是一种新的、简单且廉价的亚临床炎症标志物。 NLR 最近被用作慢性疾病的全身炎症标志物以及心血管疾病和恶性肿瘤的预后预测因子。目的：本研究的目的是探讨老年人群中NLR与糖尿病（DM）微血管并发症之间的关系。对象和方法：242 名 DM 患者（145 名有并发症的糖尿病患者，97 名无并发症的糖尿病患者）和 218 名对照受试者参加了本研究。评估了 DM 引起的 NLR 和微血管并发症，并与其他炎症标志物进行了比较。结果：糖尿病组的NLR（2.21+/-1.14）高于对照组（2.18+/-0.76）。此外，有和没有并发症的糖尿病患者的 NLR 水平之间存在统计学显着差异（分别为 2.46+/-1.26 vs 2.04+/-0.51；p
Background: Chronic inflammation plays an important role on development and progression of Type 2 diabetes (T2DM) through immunologic inflammatory mechanisms. Neutrophil to lymphocyte ratio (NLR) is a new, simple and cheap marker of subclinical inflammation. NLR has recently been used as a systemic inflammation marker in chronic diseases as well as a predictor of prognosis in cardiovascular diseases and malignancies. Aim: The objective of the present study was to investigate the relationship between NLR and microvascular complications of diabetes mellitus (DM) in elderly population. Subjects and methods: Two hundred and forty-two patients with DM (145 diabetic patients with complications, 97 diabetic patients without complications) and 218 control subjects were enrolled in this study. NLR and microvascular complications because of DM were evaluated and compared with other inflammatory markers. Results: NLR was higher in the diabetic group (2.21+/-1.14) than in the controls (2.18+/-0.76). Furthermore, there was a statistically significant difference between NLR levels in diabetic patients with and without complications (2.46+/-1.26 vs 2.04+/-0.51, respectively; p