Influenza: historical aspects of epidemics and pandemics
Influenza: historical aspects of epidemics and pandemics
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DOI：
10.1016/s0891-5520(03)00095-3
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发表时间：
2004-03-01
影响因子：
4.4
通讯作者：
Cunha, BA
中科院分区：
文献类型：
--
作者：
Cunha, BA
流感是一种人畜共患呼吸道病毒，影响鸟类、哺乳动物和人类。流感病毒在其遗传不稳定性方面是独特的，这经常导致抗原漂移或转移。抗原变化是流感流行的原因。在过去的几百年里，甲型流感大流行已经造成数百万人死亡。就毒力和致死率而言，1918年至1919年的流感大流行是历史上最严重的。它在年轻健康成年人中的偏好和致命性是独一无二的。对于1918年至1919年大流行的异常毒性，从来没有一个令人满意的解释。
Influenza is a zoonotic respiratory virus that affects birds, mammals, and humans. Influenza viruses are unique in their genetic instability, which frequently results in antigenic drift or shift. Antigenic shifts are responsible for influenza epidemics. Influenza A pandemics have been responsible for millions of deaths during the past several hundred years. In terms of virulence and lethality, the 1918 to 1919 influenza pandemic was the worst in history. It was unique in its predilection and lethality among young healthy adults. There has never been a satisfactory explanation for the unusual virulence of the 1918 to 1919 pandemic.