Evaluation of retinal nonperfusion in branch retinal vein occlusion using wide-field optical coherence tomography angiography
Evaluation of retinal nonperfusion in branch retinal vein occlusion using wide-field optical coherence tomography angiography
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DOI：
10.1111/aos.14087
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发表时间：
2019-09-01
影响因子：
3.4
通讯作者：
Nishida, Kohji
中科院分区：
文献类型：
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作者：
Shiraki, Akihiko;Sakimoto, Susumu;Nishida, Kohji
目的探讨视网膜分支静脉闭塞（BRVO）眼视网膜非灌注的宽视场光学相干断层血管造影（OCTA）特征。方法在本机构横断面研究中，对27例BRVO患者的27只眼睛进行连续病例系列的5个12 × 12 mm扫源OCTA和宽视场荧光素血管造影（FA）图像的自动扫描。评估两种检查检测到的视网膜非灌注区域之间的相关性。对视网膜非灌注眼的5个12 x 12 mm OCTA扫描获得的全景图像进行二值化或骨架化，并评估血管密度（VD）和血管长度（VL）等血管参数与宽视场FA特征之间的关系。结果OCTA图像视网膜非灌注区平均面积为81.0 +/- 66.8 mm(2)（范围为0.0-188.8）。FA和总FA图像中视网膜非灌注的平均面积分别为84.7 +/- 72.5 mm(2)（范围0.0-221.9）和184.1 +/- 167.7 mm(2)（范围0.0-515.0）。平均VD为27.6 +/- 3.5%（范围19.6-33.7），平均VL为12.4 +/- 8.5%（范围5.4-31.3）。单独回归分析FA图像中视网膜非灌注区域（p = 0.0004, R-2 = 0.4627）和总FA图像（p = 0.0008, R-2 = 0.4214）与VL有显著相关性。结论基于宽视场技术的OCTA图像可定量评价BRVO眼视网膜非灌注。
Purpose To characterize wide-field optical coherence tomography angiography (OCTA) features of retinal nonperfusion in eyes with branch retinal vein occlusion (BRVO). Methods Automated scanning of five 12 x 12-mm areas of swept-source OCTA and wide-field fluorescein angiography (FA) images was performed in a consecutive case series of 27 eyes in 27 patients with BRVO in this institutional cross-sectional study. The correlation between the areas of retinal nonperfusion detected by both examinations was assessed. Panoramic images obtained in five 12 x 12-mm OCTA scans in eyes with retinal nonperfusion were binarized or skeletonized, and the associations between vascular parameters such as vascular density (VD) and vascular length (VL) with the wide-field FA characteristics were evaluated. Results The mean area of retinal nonperfusion in the OCTA images was 81.0 +/- 66.8 mm(2) (range, 0.0-188.8). The mean areas of retinal nonperfusion in FA and the total FA images were, respectively, 84.7 +/- 72.5 mm(2) (range, 0.0-221.9) and 184.1 +/- 167.7 mm(2) (range, 0.0-515.0). The mean VD was 27.6 +/- 3.5% (range, 19.6-33.7), and the mean VL was 12.4 +/- 8.5% (range, 5.4-31.3). Separate regression analyses of the areas of retinal nonperfusion in FA (p = 0.0004, R-2 = 0.4627) and the total FA (p = 0.0008, R-2 = 0.4214) images showed a significant association with the VL. Conclusions OCTA images based on wide-field technologies can quantitatively evaluate retinal nonperfusion in eyes with BRVO.