THE INTER-REGIONAL EPIDEMIOLOGICAL-STUDY OF CHILDHOOD-CANCER (IRESCC) - CASE CONTROL STUDY OF CHILDREN WITH BONE AND SOFT-TISSUE SARCOMAS
THE INTER-REGIONAL EPIDEMIOLOGICAL-STUDY OF CHILDHOOD-CANCER (IRESCC) - CASE CONTROL STUDY OF CHILDREN WITH BONE AND SOFT-TISSUE SARCOMAS
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DOI：
10.1038/bjc.1988.321
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发表时间：
1988-12-01
影响因子：
8.8
通讯作者：
WATERHOUSE, JAH
中科院分区：
文献类型：
--
作者：
HARTLEY, AL;BIRCH, JM;WATERHOUSE, JAH
儿童癌症的区域间流行病学研究包括43例软组织和30例骨肉瘤，以及146例匹配的对照。广泛的病因学因素的分析显示，在指数怀孕，早期的医疗经验的情况下，儿童，或父母的医疗，职业和吸烟史的事件相关的风险因素很少。确实出现的关联包括：尤文氏瘤儿童出生体重较低，怀孕期间有毒血症症状的软组织肉瘤儿童的母亲过多;以及出生后不久接受抗生素治疗的横纹肌肉瘤儿童更多。有一些证据表明，患有软组织肉瘤的儿童的母亲可能会降低生育能力，而没有其他妊娠的母亲的生育能力明显过剩。轻微过度的先天性畸形的情况下，儿童和恶性和良性/边缘性肿瘤疾病的高龄母亲是一致的存在一定程度的遗传易感性的肿瘤的发展，在这个系列。
The Inter-Regional Epidemiological Study of Childhood Cancer included 43 cases of soft tissue and 30 cases of bone sarcomas, together with their 146 matched controls. Analysis of a wide range of aetiological factors revealed few risk factors relating to events during the index pregnancy, the earlier medical experiences of the case child, or parental medical, occupational and smoking history. Associations which did emerge included: lower birth weight in children with Ewing''s tumour, an excess of mothers of children with soft tissue sarcoma with symptoms of toxaemia in pregnancy; and more children with rhabdomyosarcoma who received antibiotics soon after birth. There was some evidence that mothers of children with soft tissue sarcoma may have had reduced fertility with a significant excess of the case mothers having no other pregnancies. Slight excesses of congenital malformations in the case children and of malignant and benign/borderline neoplastic disease in the older mothers were consistent with the existence of a degree of genetic predisposition in the development of the tumours in this series.