Effects of subclinical depression, anxiety and somatization on brain structure in healthy subjects
Effects of subclinical depression, anxiety and somatization on brain structure in healthy subjects
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DOI：
10.1016/j.jad.2017.03.039
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发表时间：
2017-06-01
影响因子：
6.6
通讯作者：
Nenadic, Igor
中科院分区：
文献类型：
--
作者：
Besteher, Bianca;Gaser, Christian;Nenadic, Igor
背景资料：在高度流行的精神疾病，如抑郁症或焦虑症的维度方法可以导致更好地了解发病机制和早期发现和预防的优势。为了更好地了解整个抑郁症/焦虑症谱的脑结构变异的关联，我们调查了轻微的亚临床症状在非临床healthy population.Methods：我们研究了177名健康受试者从社区，谁接受了高分辨率钛加权3 T MRI，并完成了SCL-90检查表（SCL-90-R）。使用CAT 12软件进行基于体素的形态计量学（VBM）分析，将SCL-90-R抑郁、焦虑和躯体化分量表与脑灰质进行相关分析。抑郁分量表与Rolandic岛盖、上级颞回（左）和中央后回的灰质呈正相关焦虑与双侧颞中回、Rolandic岛盖、扣带回中回、楔前叶正相关，躯体化与左侧下前额叶正相关。躯体化与小脑蚓部和右侧辅助运动区也呈负相关。局限性：我们的研究仅限于VBM，不包括基于表面的措施。它也只包含科目非常小的心理困扰部分重叠symptoms.Conclusion：我们的研究结果是一致的，在几个大脑区域的情绪调节以及改变在临床表现的抑郁/焦虑障碍的症状严重程度和皮质体积之间的非线性关系。
Background: Dimensional approaches in highly prevalent psychiatric disorders like depression or anxiety could lead to a better understanding of pathogenesis and advantages in early detection and prevention. In an effort to better understand associations of brain structural variation across the depression/anxiety spectra, we investigated minor subclinical symptoms in a non-clinical healthy population.Methods: We studied 177 healthy subjects from the community, who underwent high-resolution Ti-weighted 3T MRI and completed the symptom-checklist-90 (SCL-90-R). Using voxel-based morphometry (VBM) analysis with CAT12 software, we correlated SCL-90-R-subscales for depression, anxiety, and somatization with gray matter across the brain.Results: Significant positive gray matter correlations emerged across all three scales in different areas: the depression subscale correlated positively with gray matter in the Rolandic operculum, superior temporal gyrus (left) and postcentral gyrus (bilateral), the anxiety subscale correlated positively with middle temporal gyrus, Rolandic operculum, middle cingular gyrus and precuneus bilaterally, and the somatization subscale with left inferior prefrontal cortex. Somatization also showed negative correlations with cerebellar vermis and right supplementary motor area.Limitations: Our study is limited to VBM and does not include surface-based measures. It also only contains subjects with very small psychological distress by partly overlapping symptoms.Conclusion: Our findings are consistent with a non-linear relationship between symptom severity and cortical volume in several brain areas involved in both emotion regulation as well as altered in clinically manifest depressive/anxiety disorders.