Recent Progress in Shigella and Burkholderia pseudomallei Vaccines.
Recent Progress in Shigella and Burkholderia pseudomallei Vaccines.
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DOI：
10.3390/pathogens10111353
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发表时间：
2021-10-20
期刊：
影响因子：
--
通讯作者：
Khakhum N
中科院分区：
文献类型：
--
作者：
Chapartegui-González I;Bowser S;Torres AG;Khakhum N
针对细菌病原体的疫苗的开发已经取得了重大进展。然而，在评价针对细胞内细菌病原体的疫苗期间发现了几个障碍。因此，可以从针对不相关的细胞内病原体开发的不同疫苗中吸取新的教训。细菌性痢疾和类鼻疽是发展中国家发病率和死亡率的重要原因，它们分别由细胞内细菌志贺氏菌和类鼻疽伯克霍尔德菌引起。尽管细菌感染、传播和感染途径的机制没有提供关于这些细菌的致病性感染过程的共性的线索，但最近评估的各种疫苗平台表明，除了抗体的刺激之外，鉴定保护性抗原和诱导T细胞应答是诱导有效保护的一些额外的必需元素。在这篇综述中，我们对最近用于对抗这两种传染性病原体的候选疫苗进行了比较评估，强调了可以帮助研究人员将有效和保护性疫苗推向临床试验的共同策略。
Significant advancement has been made in the development of vaccines against bacterial pathogens. However, several roadblocks have been found during the evaluation of vaccines against intracellular bacterial pathogens. Therefore, new lessons could be learned from different vaccines developed against unrelated intracellular pathogens. Bacillary dysentery and melioidosis are important causes of morbidity and mortality in developing nations, which are caused by the intracellular bacteria Shigella and Burkholderia pseudomallei, respectively. Although the mechanisms of bacterial infection, dissemination, and route of infection do not provide clues about the commonalities of the pathogenic infectious processes of these bacteria, a wide variety of vaccine platforms recently evaluated suggest that in addition to the stimulation of antibodies, identifying protective antigens and inducing T cell responses are some additional required elements to induce effective protection. In this review, we perform a comparative evaluation of recent candidate vaccines used to combat these two infectious agents, emphasizing the common strategies that can help investigators advance effective and protective vaccines to clinical trials.
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