Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents
Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents
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DOI：
10.1016/s2221-1691(12)60075-6
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发表时间：
2012-06-01
影响因子：
1.7
通讯作者：
Rao, Chandana Venkateswara
中科院分区：
文献类型：
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作者：
Hussain, Talib;Gupta, Ramesh K.;Rao, Chandana Venkateswara
目的：研究黄果茄的保肝作用。黄果果实提取物对抗抗结核药物引起的实验动物肝毒性。方法：采用50%乙醇提取法。在实验动物中，每天给35只产蛋的大鼠施用黄果芸香（100、200和100 mg/kg bw）。三种抗结核药物[异烟肼（7.5 mg/kg.利福平（R）10 mg/kg和吡嗪酰胺35 mg/kg]混悬液经口给药35天。采用各种生化指标如天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）评价保肝活性。碱性磷酸酶（ALP）。总胆红素（IRE.）。所有（ALB）。总蛋白（TP）。乳酸脱氢酶（LDH）。和血清胆固醇（CHI.）。同时还具有抗氧化活性如脂质过氧化（LPO）、还原型谷胱甘肽（GSH）。过氧化物。测定大鼠肝匀浆中超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的活性。通过组织病理学检查补充生化观察结果。结果：S.黄果显著（P
Objective: To assess the hepatoprotective effect of Solanum xanthocarpum (S. xanthocarpum fruit extract against antitubercular drug induced liver toxicity in experimental animals. Methods: Ethanolic (50%) fruit extract of S. xanthocarpum (100, 200 and ton mg/kg bw) was administered daily for 35 (lays in experimental animals. Liver toxicity was induced by combination of three antitubercular drugs [isoniazid (7.5 mg/kg. rifampicin (R) 10 mg/kg and pyrazinamide 35 mg/kg] given orally as suspension for 35 days in rats. The hepatoprotective activity was assessed using various: biochemical parameters like aspartate aminotransferase (AST), alanine anti sit (ALT). alkaline phosphatise (ALP). total bilirubin (IRE.). all (ALB). total protein (TP). lactate dehydroginase (LDH). and serum cholesterol (CHI.). Meanwhile_ in pin) antioxidant activities as lipid peroxidation LPO), reduced glutathione (GSH). superoxide. dismutase (SOD) and catalase (CAT) were measured in rat liver homogenate. The biochemical observations were supplemented by histopathological examination. Results: The results demonstrated that treatment with S. xanthocarpum significantly (P