Retrospective Hair Cortisol Concentrations from Pretreatment to Early Recovery in Alcohol Use Disorder.
Retrospective Hair Cortisol Concentrations from Pretreatment to Early Recovery in Alcohol Use Disorder.
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酒精使用障碍从预处理到早期恢复的回顾性头发皮质醇浓度。
DOI：
10.1093/alcalc/agaa127
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Nixon,SaraJo
中科院分区：
文献类型：
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作者：
Price,JulianneL;Nixon,SaraJo
已知皮质醇谱在酒精使用障碍（AUD;例如，慢性使用、戒断和早期/持续恢复）的各个阶段不同。这些模式在很大程度上是通过学科间的对比建立的。使用分段头发皮质醇浓度（HCC）的方法，回顾性纵向分析是可行的。在这里，我们研究了从饮酒到戒酒的AUD寻求治疗者的每月皮质醇分泌。在约6周的恢复期，我们从患有中度至重度AUD的个体中收集毛发样本。我们检查了三个连续段的HCC：近端头皮代表最近一个月（持续戒酒），中段代表上个月戒酒，远端代表2个月前主动饮酒。分析研究了主要的和交互作用的段和性别，控制每月的酒精消费量。最佳拟合为二次型，受试者内变化显著（F1，15= 5.27，P = 0.04，η partial 2 = 0.26）。远段和中段之间没有差异（P= 0.51）。近端节段明显低于远端节段（M = 0.200，P = 0.004）和中段（M = 0.175，P < 0.001）。性别效应接近显著性，提示女性HCC发病率略高于男性（MWOMEN= 1.37vs.MMEN = 1.02，P = 0.10）。与以前的横断面报告一致，这些数据证实了皮质醇积累的非线性模式，在饮酒和禁欲期间明显升高。通过HCC轨迹捕获这些受试者内模式可以作为识别与风险增加和治疗后结局相关的特征的宝贵资源。
Cortisol profiles are known to vary across phases of alcohol use disorder (AUD; e.g. chronic use, withdrawal and early/sustained recovery). These patterns have largely been established through between-subjects contrasts. Using a segmental hair cortisol concentrations (HCC) approach, retrospective longitudinal analyses are feasible. Here, we examine monthly cortisol secretion in treatment-seekers with AUD from alcohol use to abstinence. At ~6 weeks of recovery we collected hair samples from individuals with moderate-to-severe AUD. We examined HCC from three consecutive segments; proximal to the scalp representing the most recent month (sustained abstinence from alcohol), the midsegment representing the previous month in which abstinence was attained, and the distal segment representing 2 months prior during active drinking. Analyses examined main and interactive effects of segment and sex, controlling for monthly alcohol consumption. Best fit by a quadratic shape, within-subject change was significant (F1,15= 5.27,P= 0.04,ηpartial2= 0.26). The distal and midsegments did not differ from one another (P= 0.51). The proximal segment was significantly lower than both the distal (M∆= 0.200,P= 0.004) and mid (M∆= 0.175,P< 0.001) segments. An effect of sex approached significance suggesting women had modestly higher HCC than men (MWOMEN= 1.37 vs.MMEN= 1.02,P= 0.10). Consistent with previous cross-sectional reports, these data confirm nonlinear patterns of cortisol accumulation with elevations apparent during periods of alcohol consumption and a decrease in abstinence. Capturing these within-subject patterns via HCC trajectories may serve as a valuable resource in identifying profiles associated with increased risk and post-treatment outcomes.