Oocyte cryopreservation: where are we now?
Oocyte cryopreservation: where are we now?
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DOI：
10.1093/humupd/dmw007
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发表时间：
2016-07-01
影响因子：
13.3
通讯作者：
Davies, Melanie C.
中科院分区：
文献类型：
--
作者：
Argyle, Catrin E.;Harper, Joyce C.;Davies, Melanie C.
自30年前第一例通过卵母细胞冷冻保存的活产以来，卵母细胞冷冻保存已成为ART的重要组成部分。冷冻保存技术不断发展，导致更高的成功率，并将卵母细胞冷冻保存引入全球IVF诊所。与此同时，患者的需求也在增加，特别是对所谓的“社会卵子冷冻”的需求，这种冷冻允许女性在预期与年龄相关的生育能力下降时保持生育能力。本文综述了卵母细胞冷冻保存的现状。它探讨了当前的技术和成功率，临床应用，选择性卵母细胞冷冻保存的兴起以及未来的影响。使用Web of Science和PubMed数据库检索1980年1月至2015年12月期间的出版物。使用的关键词包括“卵子冷冻”、"卵母细胞冷冻“、”卵母细胞冷冻保存“、”卵母细胞玻璃化“和”生育力恢复“。卵母细胞冷冻保存的成功率已经上升，越来越多地使用玻璃化冷冻提供了改善的结果，IVF妊娠率现在与新鲜卵母细胞相似。关于开放式玻璃化冷冻和封闭式玻璃化冷冻的相对成功率，存在着相互矛盾的观点。患者正在访问和接受卵母细胞冷冻保存用于广泛的适应症，并且患者数量和卵母细胞冷冻保存周期显着增加。卵母细胞冷冻保存用于预防年龄相关性不孕症正变得越来越被广泛接受。卵母细胞冷冻保存是ART的一个既定组成部分，玻璃化冷冻现在是首选的冷冻保存技术。越来越多的妇女由于医学和社会原因接受卵母细胞冷冻保存。重要的是要继续审计结果和报告长期随访的儿童出生的冻融卵母细胞。
Since the first live birth from oocyte cryopreservation three decades ago, oocyte cryopreservation has become an important component of ART. Cryopreservation techniques have evolved, leading to higher success rates and the introduction of oocyte cryopreservation into IVF clinics worldwide. Concurrently, there has been an increase in patient demand, especially for so-called 'social egg freezing' that allows women to preserve their fertility in anticipation of age-related fertility decline. This review addresses a need to evaluate the current status of oocyte cryopreservation. It explores current techniques and success rates, clinical applications, the rise of elective oocyte cryopreservation, and future implications.A search was performed using Web of Science and PubMed databases for publications between January 1980 and December 2015. Keywords used included 'egg freezing', 'oocyte freezing', 'oocyte cryopreservation', 'oocyte vitrification', and 'fertility preservation'.The success rate of oocyte cryopreservation has risen, and the increasing use of vitrification offers has improved outcomes, with IVF pregnancy rates now similar to those achieved with fresh oocytes. There are conflicting opinions about the comparative success rates of open and closed vitrification. Patients are accessing and receiving oocyte cryopreservation for a wide range of indications, and there has been a marked increase in patient numbers and oocyte cryopreservation cycles. Oocyte cryopreservation for circumventing age-related infertility is becoming more widely accepted.Oocyte cryopreservation is an established component of ART, with vitrification now being the cryopreservation technique of choice. Increasing numbers of women undergo oocyte cryopreservation for both medical and social reasons. It is important to continue auditing outcomes and reporting long-term follow-up of children born from frozen-thawed oocytes.