Cannabinoid influences on palatability:: microstructural analysis of sucrose drinking after Δ9-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716
Cannabinoid influences on palatability:: microstructural analysis of sucrose drinking after Δ9-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716
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DOI：
10.1007/s00213-002-1263-3
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发表时间：
2003-02-01
影响因子：
3.4
通讯作者：
Kirkham, TC
中科院分区：
文献类型：
--
作者：
Higgs, S;Williams, CM;Kirkham, TC
基本原理：中枢大麻素系统通过CB 1激动剂和拮抗剂各自的贪食和厌食作用参与食欲控制。这些行为背后的动机变化仍有待确定，但可能涉及食物适口性的改变。目的：通过检查外源性和内源性激动剂和选择性CB 1受体拮抗剂对大鼠摄入可口的蔗糖溶液中舔微结构的影响，研究了大麻素对摄入的作用模式。研究方法：对非剥夺性雄性Lister hooded大鼠给予一系列激动剂和拮抗剂剂量，进行舔10%蔗糖溶液的显微结构分析。结果：δ（9）-四氢大麻酚（0.5，1和3 mg/kg）和大麻素（1 mg/kg和3 mg/kg）显着增加舔的总数。这主要是由于回合持续时间的增加而不是回合数量的增加。2-花生四烯酸甘油（0.2、1.0和2.0 mg/kg）给药后，总舔次数无显著增加，而CB 1拮抗剂SR 141716（1 mg/kg和3 mg/kg）给药后，总舔次数显著减少。所有药物，除了花生四烯酸，显着降低回合内舔率。拟合到每种药物的累积舔率曲线的指数函数显示，所有化合物改变了该函数的渐近线，而对指数没有任何显著影响。结论：这些数据是一致的内源性大麻素参与调解食物的适口性。
Rationale: Central cannabinoid systems have been implicated in appetite control through the respective hyperphagic and anorectic actions of CB1 agonists and antagonists. The motivational changes underlying these actions remain to be determined, but may involve alterations to food palatability. Objectives: The mode of action of cannabinoids on ingestion was investigated by examining the effects of exogenous and endogenous agonists, and a selective CB1 receptor antagonist, on licking microstructure in rats ingesting a palatable sucrose solution. Methods: Microstructural analyses of licking for a 10% sucrose solution was performed over a range of agonist and antagonist doses administered to non-deprived, male Lister hooded rats. Results: Delta(9)-tetrahydrocannabinol (0.5, 1 and 3 mg/kg) and anandamide (1 mg/kg and 3 mg/kg) significantly increased total number of licks. This was primarily due to an increase in bout duration rather than bout number. There was a nonsignificant increase in total licks following administration of 2-arachidonoyl glycerol (0.2, 1.0 and 2.0 mg/kg), whereas administration of the CB1 antagonist SR141716 (1 mg/kg and 3 mg/kg) significantly decreased total licks. All drugs, with the exception of anandamide, significantly decreased the intra-bout lick rate. An exponential function fitted to the cumulative lick rate curves for each drug revealed that all compounds altered the asymptote of this function without having any marked effects on the exponent. Conclusions: These data are consistent with endocannabinoid involvement in the mediation of food palatability.