Anti-Toxoplasma host defense systems and the parasitic counterdefense mechanisms
Anti-Toxoplasma host defense systems and the parasitic counterdefense mechanisms
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DOI：
10.1016/j.parint.2022.102593
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发表时间：
2022-05-04
影响因子：
1.9
通讯作者：
Yamamoto，Masahiro
中科院分区：
文献类型：
--
作者：
Sasai，Miwa;Yamamoto，Masahiro
刚地弓形虫：一种细胞内的寄生虫，在宿主之间没有区别，能感染几乎所有温血脊椎动物。尽管大约30%的人口被认为感染了t病毒。弓形虫是最常见的机会性感染之一，在免疫系统功能正常时不会引起严重症状。在这篇综述中，我们主要关注anti-T。宿主先天免疫、获得性免疫和II型干扰素介导的细胞自主免疫引起的弓形虫感染。弓形虫有三种类型的分泌结构，即腺状体、致密颗粒和微素，其中分子从mt中释放出来。弓形虫和致密颗粒抑制宿主消除t的反应。刚。t释放的分子。弓形虫体和致密颗粒不仅可以抑制宿主免疫，还可以控制感染细胞中的基因表达，从而有利于感染的传播。刚地虫存活至今，并可能通过巧妙地将自身因素应用于被感染的宿主而继续进化。
Toxoplasma gondiiis an intracellular parasite that does not differentiate among hosts and is capable of infecting nearly all warm-blooded vertebrates. Although about 30% of the human population is thought to be infected withT. gondii, it is one of the most common opportunistic infections that does not cause serious symptoms when the immune system is functioning normally. In this review, we focus on anti-T. gondiiinfection by host innate immunity, acquired immunity, and type II interferon-mediated cell-autonomous immunity.T. gondiihas three types of secretory structures, rhoptries, dense granules, and micronemes, among which molecules released fromT. gondiivia rhoptries and dense granules act to inhibit host responses to eliminate.T. gondii.The molecules released byT. gondiithrough rhoptries and dense granules not only act to suppress host immunity, but also to control gene expression in infected cells, thereby favouring the spread of infection.T. gondiihas survived to this day, and may continue to evolve by skilfully applying its own factors to the infected host.