The geographical distribution of Kaposi's sarcoma and of lymphomas in Africa before the AIDS epidemic.
The geographical distribution of Kaposi's sarcoma and of lymphomas in Africa before the AIDS epidemic.
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DOI：
10.1038/bjc.1998.717
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发表时间：
1998-12
影响因子：
8.8
通讯作者：
Burkitt, D P
中科院分区：
文献类型：
--
作者：
Cook-Mozaffari, P;Newton, R;Beral, V;Burkitt, D P
根据艾滋病毒流行前收集的数据，给出了非洲大陆三种与人类免疫缺陷病毒(HIV)相关的癌症[卡波西氏肉瘤(KS)、伯基特淋巴瘤(BL)和其他非霍奇金淋巴瘤(NHL)]的估计发病率。绘制的比率图以及与一系列地理变量的比较表明，KS和BL的分布完全不同，但Burkitt淋巴瘤和其他NHL的发生有一定程度的相似。与世界其他地方的发病率进行比较，最值得注意的是，KS在撒哈拉以南非洲的一些地区和西欧大部分地区的结肠癌一样常见。与艾滋病时代的数据相比，乌干达和津巴布韦的卡波西肉瘤发病率增加了20倍。在西方人口中，白血病的最高发病率是年轻时白血病发病率的三到四倍，但其他非霍奇金淋巴瘤的总体发病率并不高于西方，南部非洲大部分地区的发病率非常低。
Estimated incidence rates are presented for three human immunodeficiency virus (HIV)-associated cancers [Kaposi's sarcoma (KS), Burkitt's lymphoma (BL) and other non-Hodgkin's lymphomas (NHLs)] from across the African continent, based on data collected before the HIV epidemic. Mapping of the rates and comparisons with a range of geographical variables indicate completely different distributions for KS and BL but a degree of similarity in the occurrence of Burkitt's lymphoma and other NHLs. Comparisons with rates elsewhere in the world suggest, most notably, that KS was as common in some regions of sub-Saharan Africa as was cancer of the colon in much of Western Europe. Comparison with data from the era of AIDS indicates 20-fold increases in the occurrence of Kaposi's sarcoma in Uganda and Zimbabwe. The highest rates for BL were three to four times the rates for leukaemia at young ages in Western populations, but the general incidence of other NHL was no higher than in the West and very low rates were indicated for much of southern Africa.