Longitudinal analysis of human salivary immunoglobulins, nonimmune antimicrobial agents, and microflora after tonsillectomy.
Longitudinal analysis of human salivary immunoglobulins, nonimmune antimicrobial agents, and microflora after tonsillectomy.
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扁桃体切除术后人唾液免疫球蛋白、非免疫抗菌药物和微生物区系的纵向分析。
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
P. Vilja
中科院分区：
文献类型：
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作者：
V. Kirstilä;J. Tenovuo;O. Ruuskanen;J. Suonpää;O. Meurman;P. Vilja
为了研究扁桃体在口腔区域宿主防御中的作用，从25名接受扁桃体切除术的年轻人中收集了一个术前和两个术后（1个月和6个月）的全唾液样本。分析唾液样本中选定的宿主防御因子，代表免疫（总伊加，IgG，IgM，抗变形链球菌，抗EBV，抗CMV和抗腺病毒伊加和IgG）和非免疫球蛋白（溶菌酶，乳铁蛋白，唾液过氧化物酶，硫氰酸盐，次硫氰酸盐和凝集素）介质。扁桃体切除术后，特异性IgG抗体显著降低（P < 0.04），表明扁桃体参与了对口腔抗原的局部IgG反应。总IgM水平也降低（P< 0.006），这可能在一定程度上反映了与术前频繁扁桃体炎状态相比抗原刺激减少。唾液来源的非免疫球蛋白宿主防御因子，除了乳铁蛋白，显着下降，在整个研究期间保持正常。我们的研究表明，扁桃体在局部口服IgG介导的免疫反应中发挥作用，但扁桃体切除术似乎不会导致唾液防御能力的任何显着的长期损害。
In order to study the role of tonsils in the host defense in the oral region one pre- and two postoperative (1 and 6 months) whole saliva samples were collected from 25 young adults referred for tonsillectomy. Saliva samples were analyzed for selected host defense factors, representing both immune (total IgA, IgG, IgM, anti-Streptococcus mutans, anti-EBV, anti-CMV, and anti-adenovirus IgA and IgG) and nonimmunoglobulin (lysozyme, lactoferrin, salivary peroxidases, thiocyanate, hypothiocyanite, and agglutinins) mediators. Following tonsillectomy, a significant (P < 0.04) reduction was observed in specific IgG antibodies, suggesting that tonsils participate in local IgG response to oral antigens. Total IgM levels also decreased (P< 0.006), which may to some extent reflect reduced antigenic stimuli compared to preoperative status with frequent tonsillitis. Saliva-derived nonimmunoglobulin host defense factors, except lactoferrin, which declined significantly, remained normal throughout the study period. Our study indicates that tonsils play a role in local oral IgG-mediated immune response but tonsillectomy does not seem to lead to any significant long-term impairment of salivary defense capacity.