Risk of colorectal neoplasm in patients with acromegaly: A meta-analysis
Risk of colorectal neoplasm in patients with acromegaly: A meta-analysis
复制标题
DOI：
10.3748/wjg.14.3484
复制
发表时间：
2008-06-14
影响因子：
4.3
通讯作者：
Koukoulis, Georgios
中科院分区：
文献类型：
--
作者：
Rokkas, Theodoros;Pistiolas, Dimitrios;Koukoulis, Georgios
目的：通过荟萃分析所有相关的对照study.METHODS：广泛的英语语言医学文献检索人类研究，到2007年12月，使用合适的关键词进行结直肠肿瘤肢端肥大症患者的风险。使用固定或随机效应模型（如适用）获得合并估计值[比值比（OR）和95%置信区间（CI）]。采用Cochran Q检验评估研究间的异质性，而通过构建漏斗图评估发表偏倚的可能性。结果：增生性息肉合并OR值的95% CI分别为3.557（2.587-4.891）和3.703（2.565-5.347）。总体效果的Z检验值分别为7.81和6.984（P < 0.0001）。对于结肠腺瘤，合并OR和95% CI分别为2.486（1.908-3.238）（固定效应模型）和2.537（1.914-3.364）（随机效应模型）。Z检验值分别为6.747和6.472（P < 0.0001）。对于结肠癌，固定和随机效应模型的合并OR和95% CI相同（OR，4351; 95% CI，1.533-12.354; Z = 2.762，P = 0.006）。有没有显着的异质性，没有发表偏倚在所有上述荟萃analysis.CONCLUSION：肢端肥大症与结直肠肿瘤的风险增加。(C)2008年，WIG出版社。All rights reserved.
AIM: To examine the risk of colorectal neoplasm in acromegalic patients by meta-analyzing all relevant controlled studies.METHODS: Extensive English language medical literature searches for human studies, up to December 2007, were performed using suitable keywords. Pooled estimates [odds ratio (OR) with 95% confidence intervals (CI)] were obtained using either the fixed or random-effects model as appropriate. Heterogeneity between studies was evaluated with the Cochran Q test whereas the likelihood of publication bias was assessed by constructing funnel plots. Their symmetry was estimated by the adjusted rank correlation test.RESULTS: For hyperplastic polyps the pooled ORs with 95% CI were 3.557 (2.587-4.891) by fixed effects model and 3.703 (2.565-5.347) by random effects model. The Z test values for overall effect were 7.81 and 6.984, respectively (P < 0.0001). For colon adenomas the pooled ORs with 95% CI were 2.486 (1.908-3.238) (fixed effects model) and 2.537 (1.914-3.364) (random effects model). The Z test values were 6.747 and 6.472, respectively (P < 0.0001). For colon cancer the pooled OR with 95% CI was identical for both fixed and random effects model (OR, 4351; 95% CI, 1.533-12.354; Z = 2.762, P = 0.006]. There was no significant heterogeneity and no publication bias in all the above meta-analyses.CONCLUSION: Acromegaly is associated with an increased risk of colorectal neoplasm. (C) 2008 The WIG Press. All rights reserved.