Beneficial effect of hydroxyfasudil, a specific Rho-kinase inhibitor, on ischemia/reperfusion injury in canine coronary microcirculation in vivo
Beneficial effect of hydroxyfasudil, a specific Rho-kinase inhibitor, on ischemia/reperfusion injury in canine coronary microcirculation in vivo
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DOI：
10.1016/j.jacc.2004.10.053
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发表时间：
2005-02-15
影响因子：
24
通讯作者：
Kajiya, F
中科院分区：
文献类型：
--
作者：
Yada, T;Shimokawa, H;Kajiya, F
本实验研究了Rho激酶特异性抑制剂羟基法舒地尔（hydroxyfasudil）对冠状动脉缺血/再灌注（I/R）损伤的保护作用，以及一氧化氮（NO）的参与。然而它是否也参与缺血/再灌注（I/R）损伤仍有待研究。方法犬心外膜下小动脉（SA，大于或等于100 μ m）和小动脉（A，
OBJECTIVES We examined whether hydroxyfasudil, a specific Rho-kinase inhibitor, exerts cardioprotective effect on coronary ischemia/reperfusion (I/R) injury and, if so, whether nitric oxide (NO) is involved.BACKGROUND Recent studies have demonstrated that Rho-kinase is substantially involved in the pathogenesis of cardiovascular diseases; however, it remains to be examined whether it is also involved in ischemia/reperfusion (I/R) injury.METHODS Canine subepicardial small arteries (SA, greater than or equal to100 mum) and arterioles (A,