Relationship between plasma glucose concentrations and native Hawaiian ancestry: the native Hawaiian health research project
Relationship between plasma glucose concentrations and native Hawaiian ancestry: the native Hawaiian health research project
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DOI：
10.1038/sj.ijo.0802000
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发表时间：
2002-06-01
影响因子：
4.9
通讯作者：
Curb, JD
中科院分区：
文献类型：
--
作者：
Grandinetti, A;Kaholokula, JK;Curb, JD
目的：探讨空腹血糖和2小时血糖与夏威夷血统和ethnicemulsider.DESIGN的百分比之间的关系：2型糖尿病和心脏病危险因素的流行病学横断面研究Hawaiians.SUBJECTS：共578夏威夷原住民居住在两个农村社区之间的1993年和1996年进行了检查。在统计分析中的样本量不同，由于缺失的数据和选择标准的基础上ethnic ancestry.MEASUREMENTS：夏威夷血统和非夏威夷种族混合物的百分比，自我报告评估。空腹和葡萄糖激发后2小时的血糖水平。人体测量（身高、体重、腰围和臀围）。饮食和体力活动的自我报告。病史。结果：夏威夷血容量的增加与空腹血糖的增加（P = 0.0047）、体重指数（BMI; P < 0.0001）、腰臀比（WHR; P = 0.0103）和年龄（P < 0.0001）显著相关，但与休闲时间体力活动和总膳食热量摄入无关。这种关联在调整BMI和WHR后减弱，但仅通过年龄调整并没有减弱。然而，当在一个参与者子集中检查来自其他种族群体的影响时，在调整年龄，性别，BMI和WHR后，完全夏威夷人的空腹血糖浓度（7.28 mmol/l）显著高于部分夏威夷人。相比之下，部分夏威夷人主要是亚洲血统有最高的2小时葡萄糖浓度（7.62 mmol/L）。结论：这些结果表明，种族混合物可能是一个重要的，但非常复杂的，关于高患病率的2型糖尿病在这一人群中观察到的因素。这种关系的复杂性可能掩盖了早期对这一人群的观察中祖先和葡萄糖耐量之间的关系。
OBJECTIVE: To investigate the relationship between fasting glucose and 2 h glucose with percentage of Hawaiian ancestry and ethnic admixture.DESIGN: Cross-sectional epidemiological study of type 2 diabetes and heart disease risk factor prevalence among Native Hawaiians.SUBJECTS: A total of 578 Native Hawaiians residing in two rural communities were examined between 1993 and 1996. Sample sizes in statistical analyses varied due to missing data and selection criteria based on ethnic ancestry.MEASUREMENTS: Percentage of Hawaiian ancestry and non-Hawaiian ethnic admixture, assessed by self-report. Fasting and 2 h post glucose challenge plasma glucose levels. Anthropometric measures (height, weight, waist and hip circumferences). Self-report of diet and physical activity. Medical history.RESULTS: Increased Hawaiian blood quantum was significantly associated with increased fasting glucose (P = 0.0047), increased body mass index (BMI; P < 0.0001), waist-to-hip ratio (WHR; P = 0.0103), and age (P < 0.0001), but not with leisure time physical activity and total dietary caloric intake. This association was attenuated after adjusting for BMI and WHR, but not by age-adjustment alone. However, when the effects of descent from other ethnic groups was examined in a subset of participants, full-Hawaiians had significantly higher fasting glucose concentrations (7.28 mmol/l) than part-Hawaiians after adjustments for age, gender, BMI and WHR. In contrast, part-Hawaiians of predominantly Asian ancestry had the highest 2 h glucose concentrations (7.62 mmol/l).CONCLUSION: These results suggest that ethnic admixture may be an important, but extremely complex, factor concerning the high prevalence of type 2 diabetes observed among this population. The complexity of this relationship may have obscured the relationship between ancestry and glucose tolerance in earlier observations of this population.