NUCLEAR MAGNETIC-RESONANCE ANALYSIS OF ACUTE AND CHRONIC MYOCARDIAL-INFARCTION IN DOGS - ALTERATIONS IN SPIN-LATTICE RELAXATION-TIMES
NUCLEAR MAGNETIC-RESONANCE ANALYSIS OF ACUTE AND CHRONIC MYOCARDIAL-INFARCTION IN DOGS - ALTERATIONS IN SPIN-LATTICE RELAXATION-TIMES
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DOI：
10.1016/0002-8703(84)90756-7
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发表时间：
1984-01-01
影响因子：
4.8
通讯作者：
SLUTSKY, RA
中科院分区：
文献类型：
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作者：
BROWN, JJ;PECK, WW;SLUTSKY, RA
本研究的目的是评估急性和慢性缺血性损伤对狗心肌自旋晶格弛豫时间（T1）的影响。对23只狗进行左冠状动脉前降支结扎，将其分为4个实验组，并在冠状动脉闭塞后3小时（n = 6）、4天（n = 6）、21天（n = 5）和56天（n = 6）处死。使用来自心肌缺血区和对照区的组织，使用 2.5 kg 核磁推理 (NMR) 波谱仪在体外测量 T1。 3 小时组和 4 天组均显示缺血区域组织的 T1 延长（P < 0.01）。在21天组中，2个梗塞显示T1增加，2个显示T1下降，1个显示没有显着变化。 56 天梗塞的 T1 平均值低于对照心肌（P < 0.01）。发现对照心肌和梗塞心肌之间心肌水含量的差异与每个实验组中T1值的平行变化相同。对 21 天和 56 天的梗塞心肌疤痕进行病理检查，发现梗塞梗塞处存在广泛的纤维化，其 T1 值和组织含水量低于对照心肌。梗死 3 小时和 4 天后的心肌水肿与 T1 延长有关。梗塞（21 天）可能是水肿（T1 增加）或纤维化（T1 值低于正常心肌），而 56 天梗死是纤维化，T1 值比正常心肌短。核磁共振成像可能能够评估心肌水肿并帮助确定缺血性损伤的持续时间。
The purpose of this study was to evaluate the effects of acute and chronic ischemic injury on myocardial spin-lattice relaxation times (T1) in dogs. Ligation of the left anterior descending coronary artery was performed on 23 dogs which were divided into 4 experimental groups and killed at 3 h (n = 6), 4 days (n = 6), 21 days (n = 5) and 56 days (n = 6) after coronary occlusion. T1 was measured in vitro with a 2.5 kg nuclear magnetic reasonance (NMR) spectrometer using tissue from ischemic and control areas of the myocardium. Both the 3 h and 4 day groups showed prolongations in T1 (P < 0.01) for tissue from the ischemic area. In the 21 day group, 2 infarcts showed an increase in T1, 2 showed a decrease in T1 and 1 showed no significant change. The 56 day old infarcts had a lower mean value for T1 than control myocardium (P < 0.01). The differences in myocardial water content between control and infarcted myocardium were found to parallel changes in T1 values in each experimental group. Pathologic examination of the myocardial scar from 21 and 56 day old infarcts revealed extensive fibrosis in the infarcts with lower T1 values and tissue water contents than control myocardium. Myocardial edema in 3 h and 4 day old infarcts results in association with prolongations in T1. Infarcts (21 days old) may be edematous (with increased T1) or fibrotic (with T1 values lower than normal myocardium), while 56 day old infarcts are fibrotic and have shorter T1 values than normal myocardium. NMR imaging may have the capacity to evaluate myocardial edema and help define the duration of ischemic injury.