Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment
Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment
复制标题
DOI：
10.1001/archneur.60.5.729
复制
发表时间：
2003-05-01
影响因子：
--
通讯作者：
Mesulam, MM
中科院分区：
文献类型：
--
作者：
Guillozet, AL;Weintraub, S;Mesulam, MM
背景资料：大量的神经纤维缠结（NFT）和淀粉样蛋白斑块是阿尔茨海默病（AD）的诊断标志物，但在非痴呆老年人中也可见较少数量的这些病变。现有的许多文献表明，AD的NFT与认知功能的相关性比淀粉样斑块更密切。在正常衰老和轻度认知损害（MCI）（一种经常反映AD临床前阶段的状况）中是否存在类似的关系仍然未知。目的：确定β-淀粉样蛋白斑块和NFT的分布模式以及这些病变与非痴呆个体记忆表现的相关性。我们调查了认知正常老年人和MCI受试者中NFT和淀粉样斑块的区域分布和神经心理学相关性，这些受试者之前接受过神经心理学测试。death.Subjects:八名非痴呆受试者自愿接受年度神经心理学测试，并同意大脑捐赠进行了研究。5名受试者没有表现出认知障碍，3名被诊断出患有轻度认知障碍。结果：NFT的分布遵循严格的分层模式，但淀粉样斑块的分布在个体之间存在差异。MCI患者的NFT密度高于非MCI患者。此外，NFT密度在颞叶与记忆分数，而密度的淀粉样蛋白斑块doesn 't.Conclusions：neurophysiary缠结是更多的内侧，颞叶区域与记忆功能，并表现出一种关系，在非痴呆症患者的记忆测试的性能。这些结果表明，NFTs可能不仅在AD中，而且在正常老化和MCI中构成记忆丧失的病理基质。
Background: Large numbers of neurofibrillary tangles (NFTs) and amyloid plaques are diagnostic markers for Alzheimer disease (AD), but lesser numbers of these lesions are also seen in nondemented elderly individuals. Much of the existing literature suggests that the NFTs of AD have a closer correlation with cognitive function than do amyloid plaques. Whether a similar relationship exists in normal aging and mild cognitive impairment (MCI), a condition that frequently reflects a preclinical stage of AD, remains unknown.Objective: To determine the distribution patterns of beta-amyloid plaques and NFTs and the association of these lesions with memory performance in nondemented individuals.Methods: We investigated regional distributions and neuropsychological correlates of NFTs and amyloid plaques in cognitively normal elderly persons and subjects with MCI who received neuropsychological testing before death.Subjects: Eight nondemented subjects who volunteered to receive annual neuropsychological testing and agreed to brain donation were studied. Five subjects showed no,cognitive impairment, and 3 were diagnosed with MCI. Results: Distribution of NFTs followed a rigorous and hierarchical pattern, but distribution of amyloid plaques varied among individuals. Subjects with MCI displayed higher NFT densities than did nonimpaired subjects. In addition, NFT density in the temporal lobe correlated with memory scores, whereas density of amyloid plaques did not.Conclusions: Neurofibrillary tangles are more numerous in medial, temporal lobe regions associated with memory function and show a relationship to performance on memory tests in nondemented individuals. These results suggest that NFTs may constitute a pathological substrate for memory loss not only in AD but also in normal aging and MCI.