Digital Breast Tomosynthesis: Observer Performance of Clustered Microcalcification Detection on Breast Phantom Images Acquired with an Experimental System Using Variable Scan Angles, Angular Increments, and Number of Projection Views
Digital Breast Tomosynthesis: Observer Performance of Clustered Microcalcification Detection on Breast Phantom Images Acquired with an Experimental System Using Variable Scan Angles, Angular Increments, and Number of Projection Views
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DOI：
10.1148/radiol.14132722
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发表时间：
2014-12-01
期刊：
影响因子：
19.7
通讯作者：
Wei, Jun
中科院分区：
文献类型：
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作者：
Chan, Heang-Ping;Goodsitt, Mitchell M.;Wei, Jun
目的：研究微钙化簇可检测性对断层扫描角度、角度增量和数字乳腺断层合成摄影（DBT）获得的投影视图数的依赖性。材料和方法：使用一个原型DBT系统在步进和拍摄模式下对乳腺体模成像。四个5厘米厚的幻影嵌入81个模拟微钙化簇的三个斑点大小（微妙，中等，明显）进行了成像，通过使用铑靶和铑过滤器与29千伏，50毫安，和7个采集协议。固定角度增量用于四个协议（分别表示为扫描角度、角度增量和投影视图的数量：16度、1度和17; 24度、3度和9; 30度、3度和11;以及60度、3度和21），并且在三个视图中使用可变增量。（40度，可变，和13; 40度，可变，和15;和60度，可变，和21）。由6名放射科医师对重建的DBT图像进行判读，并对微小钙化簇进行定位和显着性评价。（22.5/28）至96%（26.8/28）用于七个DBT协议; 16度、1度和17度方案获得了最高的灵敏度（96%），但差异仅对60度有显著性，3度，21个协议（80%，P，0.002），其他五个协议没有达到显著性（P = 0.01 - 0.15）。检测中等和明显聚类的平均灵敏度范围为97%（29个中的28.2个）至100%（24个中的24个），但差异不显著（P = 0.08至> 0.99）。16度、1度和17度协议的细微和中等聚类的显著性被评为高于其他协议; 24度、3度和9度协议的细微聚类和24度、3度和9度协议的中等聚类; 30度、3度和11度协议; 60度、3度和21度协议的差异具有显著性。和60度，可变，和21个协议（P
Purpose: To investigate the dependence of microcalcification cluster detectability on tomographic scan angle, angular increment, and number of projection views acquired at digital breast tomosynthesis (DBT).Materials and Methods: A prototype DBT system operated in step-and-shoot mode was used to image breast phantoms. Four 5-cm-thick phantoms embedded with 81 simulated microcalcification clusters of three speck sizes (subtle, medium, and obvious) were imaged by using a rhodium target and rhodium filter with 29 kV, 50 mAs, and seven acquisition protocols. Fixed angular increments were used in four protocols (denoted as scan angle, angular increment, and number of projection views, respectively: 16 degrees, 1 degrees, and 17; 24 degrees, 3 degrees, and nine; 30 degrees, 3 degrees, and 11; and 60 degrees, 3 degrees, and 21), and variable increments were used in three (40 degrees, variable, and 13; 40 degrees, variable, and 15; and 60 degrees, variable, and 21). The reconstructed DBT images were interpreted by six radiologists who located the microcalcification clusters and rated their conspicuity.Results: The mean sensitivity for detection of subtle clusters ranged from 80% (22.5 of 28) to 96% (26.8 of 28) for the seven DBT protocols; the highest sensitivity was achieved with the 16 degrees, 1 degrees, and 17 protocol (96%), but the difference was significant only for the 60 degrees, 3 degrees, and 21 protocol (80%, P,.002) and did not reach significance for the other five protocols (P = .01-.15). The mean sensitivity for detection of medium and obvious clusters ranged from 97% (28.2 of 29) to 100% (24 of 24), but the differences fell short of significance (P =.08 to >.99). The conspicuity of subtle and medium clusters with the 16 degrees, 1 degrees, and 17 protocol was rated higher than those with other protocols; the differences were significant for subtle clusters with the 24 degrees, 3 degrees, and nine protocol and for medium clusters with 24 degrees, 3 degrees, and nine; 30 degrees, 3 degrees, and 11; 60 degrees, 3 degrees and 21; and 60 degrees, variable, and 21 protocols (P