Characteristic distribution of maculopapular rash caused by gemcitabine‐based chemotherapy
Characteristic distribution of maculopapular rash caused by gemcitabine‐based chemotherapy
复制标题
吉西他滨化疗所致斑丘疹的特征性分布
DOI：
10.1111/1346-8138.15654
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发表时间：
2020
期刊：
影响因子：
3.1
通讯作者：
K Hashine
中科院分区：
文献类型：
--
作者：
M Tohyama;A Asagi;A Nakasya;S Iuchi;K Hashine
化疗药物吉西他滨引起的皮肤毒性并不罕见，但通常是轻微的。然而，有报道称，在接受吉西他滨和其他抗癌药物联合治疗的患者中，会出现中度到重度的皮疹。这项研究的目的是评估以吉西他滨为基础的化疗引起的皮疹的特征。我们分析了12名患者，这些患者在使用吉西他滨化疗后出现了超过体表10%的斑丘疹。8例患者在首次用药后6.3天±1.3天出现斑丘疹，4例在第二次用药后出现斑疹。在两名患者中，皮疹位于躯干的外侧。10例患者除躯干外侧外，胸腹部均有不同程度的皮疹。然而，几乎所有患者的背部上部和中部都没有皮疹。皮疹消失后，8名患者重新服用吉西他滨。他们继续治疗，没有或只有轻微的皮疹复发。综上所述，以吉西他滨为基础的化疗引起的黄斑丘疹偏向于躯干的额侧部位，这可能为后续的化疗提供信息。
Skin toxicity induced by gemcitabine, a chemotherapeutic agent, is not rare, but is usually mild. However, the occurrence of moderate to severe skin rash has been reported in patients treated with combinations of gemcitabine and other anticancer drugs. The aim of this study was to assess the characteristics of rash caused by gemcitabine‐based chemotherapy. We analyzed 12 patients who developed maculopapular rash over more than 10% of their body surface following gemcitabine‐based chemotherapy. Maculopapular rash appeared at 6.3 ± 1.3 days after the first administration in eight patients and the second administration in four patients. In two patients, the rash was localized on the lateral aspect of the trunk. The other 10 patients showed various degrees of rash on the chest and abdomen, in addition to the lateral aspect of the trunk. However, rash was absent on the upper and middle back in almost all patients. After the rash disappeared, gemcitabine was re‐administrated in eight patients. They continued the therapy with no or only mild rash relapse. In conclusion, maculopapular rash caused by gemcitabine‐based chemotherapy shows biased distribution to frontal and lateral sites of the trunk, which may be informative for consecutive chemotherapy.