Characterization of patients with multiple sexually transmitted infections: A hospital-based survey
Characterization of patients with multiple sexually transmitted infections: A hospital-based survey
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多种性传播感染患者的特征：基于医院的调查
DOI：
10.4103/2589-0557.74978
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发表时间：
2010
影响因子：
0.4
通讯作者：
N. S. Mogha
中科院分区：
文献类型：
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作者：
Shilpee Choudhry;V. Ramachandran;Shukla Das;S. Bhattacharya;N. S. Mogha
背景：许多研究探讨了不同性传播感染之间的相互关系。然而，有一些关于同时患有一种以上性传播感染 (STI) 的患者的数据。该研究的目的是确定同时患有一种以上性传播感染的患者的负担，并确定与此类感染相关的因素。材料和方法：275 名患有世界卫生组织 (WHO) 在其 STI 诊断综合征方法中阐明的一种或多种主诉的患者被纳入为受试者。记录详细的病史、人口统计数据和临床特征。所有患者均接受了常见性传播感染的筛查。对从单变量分析中获得的所有显着风险因素进行多变量分析。结果：共有 102 名（37%）患者被确定患有多种性传播感染，其中 72%（73/102）为男性，70% 已婚，除 1 名没有报告经常使用安全套外，第一次性接触的年龄为 13-17 岁，31.3% 在过去 6 个月内有超过 3 个性伴侣，76.4% 与商业性工作者（CSW）有接触。多变量分析显示，婚姻状况、过去 6 个月内接触性伴侣的数量、首次性接触的年龄以及就诊时患者的年龄具有统计学意义。梅毒 (48%) 是与多种性传播感染相关的最常见感染，其次是 HIV (45%) 和 HSV-2 (39.2%)。没有一个多重感染患者能够通过症状方法得到准确的检测和管理。结论：同时发生的多种性传播感染的模式和此类多重感染的临床严重程度可以作为决定感染结果的宿主-病原体相互作用类型的指标。当患者患有多种性传播感染时，综合征方法并不是不言自明的，因此强调了实验室诊断的必要性。
Background: Many studies have examined the inter-relationship between different STI. There are, however, a few data on patients presenting with more than one concurrent sexually transmitted infection (STI). The aim of the study was to determine the burden of patients with more than one concurrent STI and to characterize factors associated with such infections. Materials and Methods: Two hundred seventy five patients with one or more of the complaints, as enunciated by the World Health Organization (WHO) in its syndromic approach for the diagnosis of STI, were included as subjects. Detailed history, demographical data, and clinical features were recorded. All the patients were screened for common STIs. Multivariate analysis was performed taking all significant risk factor obtained from univariate analysis. Results: A total of 102 (37%) patients were identified as having multiple STIs amongst whom 72% (73/102) were male, 70% were married, and except one none reported regular use of condom The age of first sexual exposure was 13–17 years, 31.3% had more than three sexual partners in the past 6 months, and 76.4% had contact with commercial sex workers (CSWs). Multivariate analysis revealed statistical significance in relation to marital status, number of sexual partners exposed in the past 6 months, age of first sexual exposure, and age of patient at the time of presentation. Syphilis (48%) was the most common infection associated with multiple STI followed by HIV (45%) and HSV-2 (39.2%). None of the patients with multiple infections were detected and managed accurately by syndromic approach. Conclusion: Pattern of concurrent multiple STIs and the clinical severity of such multiple infections may serve as an indicator of the type of host–pathogen interaction determining the outcome of infection. When patient had multiple STIs, syndromic approach was not axiomatic and thus underscores the need for laboratory diagnosis.