Escapable and inescapable stress differentially and selectively alter extracellular levels of 5-HT in the ventral hippocampus and dorsal periaqueductal gray of the rat
Escapable and inescapable stress differentially and selectively alter extracellular levels of 5-HT in the ventral hippocampus and dorsal periaqueductal gray of the rat
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DOI：
10.1016/s0006-8993(98)00368-0
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发表时间：
1998-06-22
期刊：
影响因子：
2.9
通讯作者：
Maier, SF
中科院分区：
文献类型：
--
作者：
Amat, J;Matus-Amat, P;Maier, SF
采用在体微透析技术，观察了可逃避和非可逃避电击对大鼠腹侧海马和中脑导水管周围灰质（dPAG）细胞外5-羟色胺（5-HT）含量的影响。不可避免的，但无法逃避的休克增加细胞外5-HT在腹侧海马相对于限制控制。基础水平的5-HT升高24小时后不可避免的休克，和以前不可避免的休克科目表现出夸大的5-HT反应2短暂的足电击。与此相反，逃避，但不是不可避免的休克，增加细胞外5-HT的dPAG，增加基础5-HT的dPAG 24小时后，并导致增强5-HT反应随后短暂的足电击。(C)1998 Elsevier Science B. V.保留所有权利。
The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the ventral hippocampus and dorsal periaqueductal gray (dPAG) were measured by in vivo microdialysis. Inescapable, but not escapable shock increased extracellular 5-HT in the ventral hippocampus relative to restrained controls. Basal levels of 5-HT were elevated 24 h after inescapable shock, and previously inescapably shocked subjects exhibited an exaggerated 5-HT response to 2 brief Footshocks. In contrast, escapable, but not inescapable shock, increased extracellular 5-HT in the dPAG, increased basal 5-HT in the dPAG 24 h later, and led to an enhanced 5-HT response to subsequent brief footshock. (C) 1998 Elsevier Science B.V. All rights reserved.