AGE-RELATED AND SEX-RELATED STUDY OF HEPATITIS-B VIRUS CHRONIC CARRIER STATE IN INFANTS FROM AN ENDEMIC AREA (SENEGAL)
AGE-RELATED AND SEX-RELATED STUDY OF HEPATITIS-B VIRUS CHRONIC CARRIER STATE IN INFANTS FROM AN ENDEMIC AREA (SENEGAL)
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DOI：
10.1002/jmv.1890220102
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发表时间：
1987-05-01
影响因子：
12.7
通讯作者：
DIOPMAR, I
中科院分区：
文献类型：
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作者：
COURSAGET, P;YVONNET, B;DIOPMAR, I
本报告涉及对塞内加尔155名婴儿观察到的乙型肝炎病毒（HBV）感染进行研究，目的是确定与慢性携带者状态发展有关的因素。50.3%的婴儿为慢性带菌者。这项研究证实，慢性便秘的风险与年龄有关。这种风险随着年龄的增长而迅速下降，从6个月以下婴儿的82%下降到2至3岁儿童的15%。乙型肝炎表面抗原（HBsAg）的自发消除在儿童时期HBsAg携带者中并不常见。在男性和女性慢性携带者中观察到的差异是由于两性对慢性携带者状态发展的易感性不同：HBV感染（2岁之前）导致77%的男性慢性携带者，而女性为50%。鉴于在流行地区正在开展的针对乙型肝炎病毒的免疫规划，这些结论是重要的。为了达到最大的效果，疫苗接种必须在出生时或出生后不久进行。
This report concerns hepatitis B virus (HBV) infections observed in 155 infants from Senegal, studied with a view to determining the factors involved in development of the chronic carrier state. A chronic carrier state was observed in 50.3% of the infants. This study confirms that the risk of chronic carriage is linked to age. This risk declines very rapidly with age, falling from 82% in infants under 6 months old, to 15% in children between the ages of 2 and 3 years. Spontaneous elimination of hepatitis B surface antigen (HBsAg) is uncommon in HBsAg carriers during childhood. The difference observed in chronic carriage between males and females is due to a difference in susceptibility of the two sexes to the development of the chronic carrier state: HBV infections (before 2 years of age) lead to a chronic carriage in 77% of males as against 50% of females. These conclusions are important in view of the immunisation programs being carried out against hepatitis B virus in endemic areas. For a maximum efficacy, vaccination must be carried out a birth, or shortly afterwards.