Cortisol production rate. V. Congenital virilizing adrenal hyperplasia.
Cortisol production rate. V. Congenital virilizing adrenal hyperplasia.
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皮质醇产生率。
DOI：
10.1016/s0022-3476(66)80124-5
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发表时间：
1966
期刊：
影响因子：
--
通讯作者：
B. Lawrence
中科院分区：
文献类型：
--
作者：
C. Migeon;C. Migeon;F. M. Kenney;F. M. Kenney;C. Richards;B. Lawrence
皮质醇分泌率估计在体内同位素稀释技术在16例先天性男性化肾上腺皮质增生症，所提供的数据包括2盐损失者以前发表的。这些数据与年龄匹配的对照组进行了比较。6例典型失盐型患者的CPR较低。第七名患者的临床表现出现有所延迟，盐流失相对较轻，但心率正常。7例单纯男性化患者的CPR在正常范围内。第八位也是最年轻的患者，年龄为16天，在检测到中度一过性盐丢失时CPR较低。第九名患者接受促肾上腺皮质激素刺激一周，CPR与未接受治疗的患者相似。
Cortisol secretion rates were estimated by the in vivo isotope dilution technique in 16 patients with congenital virilizing adrenal hyperplasia; the data presented includes those of 2 salt losers previously published. The data were compared with those from age-matched controls. Six patients with the typical pattern of the salt-losing form had low CPR's. A seventh patient, the appearance of whose clinical manifestations was somewhat delayed and who had relatively mild salt loss, had a normal rate. Seven patients with the simple virilizing form had CPR's within the normal range. The eighth and youngest patient, aged 16 days, had a low CPR at a time when moderate transient salt loss was detected. The ninth patient was under ACTH stimulation for one week and had a CPR similar to those of the untreated patients.