Troglitazone has a scavenging effect on reactive oxygen species.
Troglitazone has a scavenging effect on reactive oxygen species.
复制标题
曲格列酮对活性氧具有清除作用。
DOI：
10.1006/bbrc.1997.6512
复制
发表时间：
1997
影响因子：
3.1
通讯作者：
T. Komoda
中科院分区：
文献类型：
--
作者：
I. Inoue;Shigehiro Katayama;Keiichi Takahashi;Kiyohiko Negishi;Takashi Miyazaki;Masaru Sonoda;T. Komoda
曲格列酮(CS-045)是一种新开发的抗糖尿病药物，可增强胰岛素敏感性，在结构上类似于几种抗氧化剂，包括α-生育酚和普罗布考。曲格列酮的体外抗氧化活性已在四氧嘧啶诱导的高脂过氧化和高脂血症小鼠中得到证实。在本研究中，我们发现曲格列酮对黄嘌呤-黄嘌呤氧化酶产生的、由刺激的中性粒细胞产生的活性氧具有清除作用，且倾向于自由基形式。我们的结果表明曲格列酮是一种类似于α-生育酚的抗氧化剂。然而，在相同条件下，另一种噻唑烷二酮类药物吡格列酮没有清除作用。曲格列酮的抗氧化作用是由于其分子结构与α-生育酚相似，除了具有降血糖和降血脂作用外，还可能有助于预防糖尿病血管并发症。
Troglitazone (CS-045), a newly developed antidiabetic thiazolidinedione that enhances insulin sensitivity, is similar in structure to several antioxidants, including alpha-tocopherol and probucol. The in vitro antioxidant activity of troglitazone has been demonstrated in alloxan-induced hyperlipoperoxidemic and hyperlipidemic mice. In this study, we found that troglitazone had a scavenging effect on reactive oxygen produced by xanthine-xanthine oxidase and generated by stimulated neutrophils and tends to be the radical form. Our results suggest that troglitazone is an antioxidant similar to alpha-tocopherol. However, under the same conditions, pioglitazone, another thiazolidinedione drug, did not have a scavenging effect. The antioxidant action of troglitazone, which is attributable to the similarity of its molecular structure to that of alpha-tocopherol, may be of benefit in preventing diabetic vascular complications, in addition to having hypoglycemic and hypolipidemic effects.
影响因子：
158.5
作者：
NOLAN, JJ;LUDVIK, B;OLEFSKY, J
通讯作者：
OLEFSKY, J
载脂蛋白 B 衍生自由基和 α-生育酚自由基在过氧化物酶依赖性低密度脂蛋白氧化中的作用。
影响因子：
6.5
作者：
Kalyanaraman,B;Darley-Usmar,V;Struck,A;Hogg,N;Parthasarathy,S
通讯作者：
Parthasarathy,S