Lowly Expressed Human MicroRNA Genes Evolve Rapidly
Lowly Expressed Human MicroRNA Genes Evolve Rapidly
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DOI：
10.1093/molbev/msp053
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发表时间：
2009-06-01
影响因子：
10.7
通讯作者：
Li, Wen-Hsiung
中科院分区：
文献类型：
--
作者：
Liang, Han;Li, Wen-Hsiung
To study the evolution of human microRNAs (miRNAs), we examined nucleotide variation in humans, sequence divergence between species, and genomic clustering patterns for miRNAs with different expression levels. We found that expression level is a major indicator of the rate of evolution and that similar to 30% of currently annotated human miRNA genes are almost free of selective pressure.
