Automated Quantitative Assessment of Retinal Fluid Volumes as Important Biomarkers in Neovascular Age-Related Macular Degeneration.
Automated Quantitative Assessment of Retinal Fluid Volumes as Important Biomarkers in Neovascular Age-Related Macular Degeneration.
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视网膜流体体积自动定量评估是与新血管相关的黄斑变性中重要的生物标志物。
DOI：
10.1016/j.ajo.2020.12.012
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发表时间：
2021-04
影响因子：
4.2
通讯作者：
Schmidt-Erfurth U
中科院分区：
文献类型：
--
作者：
Keenan TDL;Chakravarthy U;Loewenstein A;Chew EY;Schmidt-Erfurth U
评价通过人工智能（AI）算法从OCT扫描中提取的视网膜液体体积数据在新生血管性年龄相关性黄斑变性（NV-AMD）治疗中的作用。对来自不同临床环境的视网膜图像库数据集进行了审查。临床试验（HARBOR）和试验随访（AREDS 2 - 10 Y）;真实世界（贝尔法斯特和特拉维夫三级中心）。24362次扫描，共1095只眼（HARBOR）; 4673/880只眼（贝尔法斯特）; 1470/132只眼（特拉维夫）; 511/511只眼（AREDS 2 - 10 Y）。维也纳液体监测仪或Notal OCT分析仪应用于黄斑立方体扫描。视网膜内液（IRF）、视网膜下液（SRF）和色素上皮脱离（PED）体积。在新生血管性AMD中测量的液体体积以纳升有效地表示。在初治阶段观察到不同人群的较大范围：0- 3435 nl（IRF）、0- 5018 nl（SRF）和0- 10022 nl（PED）。平均体积迅速下降，并与抗VEGF治疗一致。维持治疗期间，特拉维夫的平均IRF体积最高（100 nl），贝尔法斯特和HARBOR-PRN较低，HARBOR-monthly最低（21 nl）。所有患者的平均SRF体积均较低：30 nl（HARBOR-每月）和48- 49 nl（其他）。IRF、SRF和PED的定量测量是NV-AMD的重要生物标志物。通过AI算法可以从OCT扫描中有效提取准确的体积，以指导渗出性黄斑疾病的管理。自动液体监测在基线和随访期间识别不同NV-AMD人群的液体特征。为了研究之间的一致性，我们建议纳升作为一个方便的单位。我们探讨了在临床实践和研究中使用这些定量指标的优势。
To evaluate retinal fluid volume data extracted from OCT scans by artificial intelligence (AI) algorithms in the management of neovascular age-related macular degeneration (NV-AMD). Perspective A review was performed of retinal image repository datasets from diverse clinical settings. clinical trial (HARBOR) and trial follow-on (AREDS2-10Y); real-world (Belfast and Tel-Aviv tertiary centers). 24362 scans of 1095 eyes (HARBOR); 4673 of 880 (Belfast); 1470 of 132 (Tel-Aviv); 511 of 511 (AREDS2-10Y). Vienna Fluid Monitor or Notal OCT Analyzer applied to macular cube scans. intraretinal fluid (IRF), subretinal fluid (SRF), and pigment epithelial detachment (PED) volumes. The fluid volumes measured in neovascular AMD were expressed efficiently in nanoliters. Large ranges that differed by population were observed at the treatment-naïve stage: 0-3435nl (IRF), 0-5018nl (SRF), and 0-10022nl (PED). Mean volumes decreased rapidly and consistently with anti-VEGF therapy. During maintenance therapy, mean IRF volumes were highest in Tel-Aviv (100nl), lower in Belfast and HARBOR-PRN, and lowest in HARBOR-monthly (21nl). Mean SRF volumes were low in all: 30nl (HARBOR-monthly) and 48-49nl (others). Quantitative measures of IRF, SRF, and PED are important biomarkers in NV-AMD. Accurate volumes can be extracted efficiently from OCT scans by AI algorithms to guide the management of exudative macular diseases. Automated fluid monitoring identifies fluid characteristics in different NV-AMD populations at baseline and during follow-up. For consistency between studies, we propose the nanoliter as a convenient unit. We explore the advantages of using these quantitative metrics in clinical practice and research.
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