The structural basis of XRCC1-mediated DNA repair.
The structural basis of XRCC1-mediated DNA repair.
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DOI：
10.1016/j.dnarep.2015.02.005
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发表时间：
2015-06
期刊：
影响因子：
3.8
通讯作者：
London RE
中科院分区：
文献类型：
--
作者：
London RE
支架蛋白通过招募和组织执行多步骤修复过程所需的一整套酶，在DNA修复中发挥核心作用。X射线交叉互补基团1蛋白(XRCC1)形成单链断裂修复优化的酶复合体，但也参与其他修复途径。根据XRCC1在DNA修复中的作用，总结和评价了XRCC1相互作用的现有结构数据。还讨论了与取消特定XRCC1相互作用相关的突变方法。尽管在阐明XRCC1功能的结构基础方面已经取得了实质性的进展，但与XRCC1 DNA修复复合体的几个拟议作用相关的XRCC1招募的分子机制仍不清楚。
Scaffold proteins play a central role in DNA repair by recruiting and organizing sets of enzymes required to perform multi-step repair processes. X-ray cross complementing group 1 protein (XRCC1) forms enzyme complexes optimized for single-strand break repair, but participates in other repair pathways as well. Available structural data for XRCC1 interactions is summarized and evaluated in terms of its proposed roles in DNA repair. Mutational approaches related to the abrogation of specific XRCC1 interactions are also discussed. Although substantial progress has been made in elucidating the structural basis for XRCC1 function, the molecular mechanisms of XRCC1 recruitment related to several proposed roles of the XRCC1 DNA repair complex remain undetermined.
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作者：
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