Number and mean volume of individual submucous glands in the human tracheobronchial tree.
Number and mean volume of individual submucous glands in the human tracheobronchial tree.
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人类气管支气管树中单个粘膜下腺的数量和平均体积。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
Whimster Wf
中科院分区：
文献类型：
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作者：
Whimster Wf
对慢性支气管炎支气管腺增大的研究主要集中在腺体质量上，而不是单个腺体及其反应。除胎儿气管外，对气管、支气管腺、粘膜下腺进行系统计数的尝试以前未见报道。在这里报道的这项研究中，腺体的数量是通过直接观察导管开口和在连续切片上进行计数的。两种方法都有缺陷，但连续切片法更可靠，但难度更大。结果以气道壁的导管开口/mm2表示，并显示与先前报道的唯一观察结果(1/mm2)相同的量级。1例吸烟者和1例非吸烟者的连续切片结果显示，吸烟者的管口范围为1.80~0.58个/mm~2，非吸烟者的管口范围为1.31~0.40个/mm~2。每一代的平均体积/腺体，也是一种新的测量方法。首次对分叉区进行了研究。在这两种情况下，腺体的数量和平均大小在近端较大，并随着呼吸道代次的增加而逐渐下降，但吸烟者的腺体始终比不吸烟者更多和更大。对两个病例的统计分析必须是有限的，但结果为形态测量师提供了基线数据，并提示，作为进一步检查的假设，吸烟可能与额外的气管、支气管腺的发育有关。
Studies of bronchial gland enlargement in chronic bronchitis have concentrated on gland mass rather than individual glands and their reactions. Except in fetal tracheas, systematic attempts to count the number of tracheobronchial submucous glands have not previously been reported. In the study reported here the numbers of glands were counted both by observing their duct openings directly and in serial sections. Both methods had defects but the serial section method was the more reliable although the more arduous. The results are presented as duct openings/mm2 of airway wall and shown to be of the same order as the only previously reported observation (1/mm2). The serial section results for 1 smoker and 1 non-smoker revealed a range of 1.80-0.58 duct openings/mm2 in the smoker and 1.31-0.40 duct openings/mm2 in the non-smoker along the generations of the main, upper lobar, lingular, and inferior lingular bronchi. The mean volume/gland, a new measurement is also reported for each generation. Bifurcation zones were studied for the first time. In both cases the numbers and mean size of the glands were greater proximally and declined progressively along the airway generations, but in the smoker the glands were consistently more numerous and larger than in the non-smoker. Statistical analysis of 2 cases must be limited but the results provide baseline data for morphometrists and suggest, as a hypothesis for further examination, that smoking may be associated with the development of additional tracheobronchial glands.