Hyperhomocysteinemia Exaggerates Adventitial Inflammation and Angiotensin II-Induced Abdominal Aortic Aneurysm in Mice
Hyperhomocysteinemia Exaggerates Adventitial Inflammation and Angiotensin II-Induced Abdominal Aortic Aneurysm in Mice
复制标题
高同型半胱氨酸血症会加剧小鼠外膜炎症和血管紧张素 II 诱导的腹主动脉瘤
DOI：
10.1161/circresaha.112.270520
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发表时间：
2012-10-26
影响因子：
20.1
通讯作者：
Wang, Xian
中科院分区：
文献类型：
--
作者：
Liu, Ziyi;Luo, Hongzhi;Wang, Xian
基本原理：许多流行病学研究表明，高同型半胱氨酸血症（HHcy）和腹主动脉瘤（AAA）的关联，但存在差异。此外，我们缺乏直接的证据支持的因果role.Objective：我们确定的协会和贡献的高同型半胱氨酸AAA formation.Methods和结果：我们首先进行了一项荟萃分析的研究，涉及1489名受试者，发现了一个强有力的协会高同型半胱氨酸和AAA（优势比，7.39）。接下来，我们使用血管紧张素II输注的雄性载脂蛋白E缺陷小鼠，并测试HHcy是否有助于AAA的发病机制。饮用水中添加同型半胱氨酸（Hcy）1.8g/L可导致轻度HHcy。有趣的是，在载脂蛋白E缺陷小鼠中，HHcy大大增加了血管紧张素II诱导的AAA和主动脉夹层的发生率（赋形剂与Hcy：50%对100%; P
Rationale: A number of epidemiological studies have suggested an association of hyperhomocysteinemia (HHcy) and abdominal aortic aneurysm (AAA), but discrepancies exist. In addition, we lack direct evidence supporting a causal role.Objective: We determined the association and contribution of HHcy to AAA formation.Methods and Results: We first performed a meta-analysis of studies involving 1489 subjects and found a strong association of HHcy and AAA (odds ratio, 7.39). Next, we used angiotensin II-infused male apolipoprotein E-deficient mice and tested whether HHcy contributes to AAA pathogenesis. Homocysteine (Hcy) supplement (1.8 g/L) in drinking water resulted in mild HHcy. Intriguingly, HHcy greatly increased the incidence of angiotensin II-induced AAA and aortic dissection in apolipoprotein E-deficient mice (vehicle versus Hcy: 50% versus 100%; P