The functional interactions of commensal bacteria with intestinal secretory IgA
The functional interactions of commensal bacteria with intestinal secretory IgA
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DOI：
10.1097/mog.0b013e3282f0d012
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发表时间：
2007-11-01
影响因子：
2.5
通讯作者：
Slack, Emma
中科院分区：
文献类型：
--
作者：
Macpherson, Andrew J.;Slack, Emma
综述的目的-这篇文章的目的是描述免疫地理学的伊加诱导肠道细菌和树突状细胞，B细胞和T细胞之间的细胞因子和共刺激信号的潜在机制。最近的研究结果肠树突状细胞样本的肠道细菌，穿透上皮层，并诱导伊加+ B细胞接种的伊加浆细胞的粘膜。肠树突状细胞组成性分泌视黄酸指导派尔集合淋巴结B细胞伊加类转换和归巢受体表达的特异性体内实验表明，TGF-β是体内伊加诱导的重要细胞因子，肿瘤坏死因子家族成员BAFF和APRIL提供关键的共刺激信号。通过上皮层运输后，分泌型伊加限制共生细菌渗透回上皮，并塑造肠腔中不同细菌物种的密度。伊加的产生是对肠道细菌存在的重要适应，并且应答的诱导在肠粘膜免疫系统内被区室化。这种区室化允许对细菌的强烈粘膜免疫应答，而不需要系统免疫系统对这些生物体具有耐受性。
Purpose of review The aim of this article is to describe the immune geography of IgA induction by commensal intestinal bacteria and the underlying mechanisms of cytokine and costimulatory signalling between dendritic cells, B cells and T cells. Recent findings Intestinal dendritic cells sample commensal intestinal bacteria that penetrate the epithelial layer and induce IgA+ B cells to seed the mucosa with IgA plasma cells. Constitutive secretion of retinoic acid by intestinal dendritic cells directs the specificity of the IgA class switch and homing receptor expression in Peyer's patch B cells. In-vivo experiments have shown that TGF-beta is a vital cytokine for IgA induction in vivo, and the tumour necrosis factor family members BAFF and APRIL provide key costimulatory signals. After transport through the epithelial layer secretory IgA limits penetration of commensal bacteria back through the epithelium and shapes the density of different bacterial species in the intestinal lumen. Summary Production of IgA is an important adaptation to the presence of commensal intestinal bacteria and induction of the response is compartmentalized within the intestinal mucosal immune system. This compartmentalization allows a vigorous mucosal immune response to commensals without needing the systemic immune system to be tolerant of these organisms.