Borreliacidal antibody production against outer surface protein C of Borrelia burgdorferi
Borreliacidal antibody production against outer surface protein C of Borrelia burgdorferi
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DOI：
10.1086/515382
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发表时间：
1998-09-01
影响因子：
6.4
通讯作者：
Wieneke, CA
中科院分区：
文献类型：
--
作者：
Rousselle, JC;Callister, SM;Wieneke, CA
鉴定了具有显著滴度的抗外表面蛋白C（OspC）杀疏螺旋体抗体的早期莱姆疏螺旋体病血清。人抗OspC杀疏螺旋体抗体可以是IgM或IgG。用OspC疫苗接种小鼠后检测到显着浓度的杀疏螺旋体活性，抗OspC杀疏螺旋体活性的检测取决于伯氏疏螺旋体分离株50772的OspC表面表达，OspC在体内和疫苗接种后诱导杀疏螺旋体抗体的能力提供了另一种可能的解释OspC疫苗接种保护免受B感染的能力。此外，在早期莱姆疏螺旋体病血清中检测抗OspC杀疏螺旋体抗体，特别是IgM抗体，提供了杀疏螺旋体抗体检测可用于早期莱姆疏螺旋体病的血清学诊断的额外证据。
Early Lyme borreliosis sera with significant titers of anti-outer surface protein C (OspC) borreliacidal antibodies were identified. Human anti-OspC borreliacidal antibodies could be either IgM or IgG. Significant concentrations of borreliacidal activity were detected after vaccination of mice with OspC, Detection of anti-OspC borreliacidal activity was dependent on surface expression of OspC by Borrelia burgdorferi isolate 50772, The ability of OspC to induce borreliacidal antibodies in vivo and after vaccination offers another possible explanation for the ability of vaccination with OspC to protect against infection with B. burgdorferi, Furthermore, detection of anti-OspC borreliacidal antibodies, especially IgM antibodies, in early Lyme borreliosis sera provides additional evidence that borreliacidal antibody detection may be useful for the serodiagnosis of early Lyme borreliosis.