Subclinical hypothyroidism and the risk of hypercholesterolemia.
Subclinical hypothyroidism and the risk of hypercholesterolemia.
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DOI：
10.4103/2249-4863.201177
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发表时间：
2016-10
影响因子：
1.4
通讯作者：
Puthuran P
中科院分区：
文献类型：
--
作者：
Jayasingh IA;Puthuran P
亚临床甲状腺功能减退症(SCH)是一种甲状腺刺激素(TSH)略有升高，但循环中游离甲状腺激素(FT4)水平正常的情况。甲状腺功能的改变会导致脂蛋白组成和运输的改变。这项研究是在埃尔纳库拉姆卢尔德医院的门诊部进行的。研究对象为110例年龄在40~69岁之间的患者，其中60例通过横断面调查确诊为SCH，随机选择50例患者作为EU组。数据基于访谈、临床检查、甲状腺功能、血脂谱。用于计算p值的学生t检验，卡方检验。SCH多见于女性(66.66%)和40~49岁组(61.66%)。亚临床甲状腺功能减退组的平均胆固醇值升高与年龄(60-69岁)和性别有关。统计分析表明，总胆固醇(TC)(P<；0.005)和甘油三酯(P<；005)与年龄(40-49岁)有显著差异。在两组人之间。A组5-7.49 Mu/L和B组7.5-10 Mu/L与甲状腺功能正常组N&5 Mu/L比较，两组平均胆固醇值均升高。亚临床甲状腺功能减退组B和甲状腺功能正常组N之间的胆固醇值有统计学意义的差异(P<；0.0005)。SCH似乎与女性和60岁年龄组的平均胆固醇水平升高有关。根据TSH值，SCH患者的两个亚组(A和B)的TC值均升高。
Subclinical hypothyroidism (SCH) is a condition wherein there are small elevations in thyroid stimulating hormone (TSH), yet normal circulating levels of free thyroid hormones (FT4). Alterations in thyroid function result in changes in composition and transport of lipoproteins. The study was undertaken in the outpatient department of Lourdes hospital, Ernakulam. 110 patients between 40-69 years were studied, of which 60 were identified to have SCH based on cross-sectional survey, 50 patients were randomly selected to represent the EU group. Data based on interview, clinical examination, thyroid function, lipid profiles. Student's t, chi-square tests used for computation of p values. SCH were seen in females (66.66%) and in the age group of 40-49 years (61.66%). Mean cholesterol values were elevated in the subclinical hypothyroid group and in relation to age (60-69) and gender. Statistical analysis showed significant difference in total cholesterol(TC) (P<0.005) and triglycerides (P<0.05) in relation to age (40–49 yrs.) between two groups. Based on TSH, group A 5-7.49Mu/L and group B 7.5-10Mu/L were compared to the euthyroid group N<5Mu/L. Mean cholesterol values were raised in both subgroups. Statistically significant difference seen (P<0.0005) in cholesterol values between the subclinical hypothyroid group B and the euthyroid group N. SCH appears to be associated with increased mean cholesterol levels in females and of age > 60 years. The TC values were elevated in both subgroups of patients with SCH (A and B) based on TSH values.