Moderate maternal alcohol consumption and risk of spontaneous abortion.
Moderate maternal alcohol consumption and risk of spontaneous abortion.
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母亲适度饮酒和自然流产的风险。
DOI：
10.1097/00001648-199709000-00007
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Swan,SH
中科院分区：
文献类型：
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作者：
Windham,GC;VonBehren,J;Fenster,L;Schaefer,C;Swan,SH
众所周知，母亲酗酒会对生殖和胎儿发育产生不利影响，但适度饮酒的影响仍然存在争议。在之前的一项病例对照研究中，我们发现，在怀孕的头三个月，每周平均喝七杯或更多的酒，自然流产的风险会增加一倍。为了证实这一发现，同时避免病例对照设计的潜在偏倚，我们在一项超过5,000名孕妇的前瞻性队列研究中检查了适度饮酒。在怀孕前三个月的一次采访中，询问了采访前一周（“怀孕前三个月”）和怀孕前的饮酒情况。我们发现，在妊娠早期每周饮酒超过3次的女性中，自然流产的风险增加，调整后的比值比（OR）为2.3 [95%置信区间（CI）= 1.1-4.5]。与这种适度饮酒相关的风险增加在妊娠早期可能高于妊娠中期，并且在前10周甚至更高（OR= 3.8; 95%CI = 1.7-8.7），基于少量数据。怀孕前饮酒与自然流产没有很强的相关性。
Maternal alcoholism is known to have adverse effects on reproduction and fetal development, but the effects of moderate consumption remain controversial. In a previous case-control study, we found a doubled risk of spontaneous abortion with an average consumption of seven or more drinks per week during the first trimester. To confirm this finding while avoiding potential biases from the case-control design, we examined moderate alcohol consumption in a prospective cohort study of over 5,000 pregnant women. An interview in the first trimester asked about alcohol consumption during the week before interview (“during the first trimester”) and before pregnancy. We found an increased risk of spontaneous abortion in women who drank more than three drinks per week during the first trimester, with an adjusted odds ratio (OR) of 2.3 [95% confidence interval (CI)= 1.1–4.5]. The increased risk associated with this moderate alcohol consumption may be higher in first than in second trimester abortions, and it is even higher in the first 10 weeks (OR= 3.8; 95% CI= 1.7–8.7), based on small numbers. Consumption of alcohol before pregnancy was not strongly associated with spontaneous abortion.