Moderate alcohol consumption and lipoprotein-associated phospholipase A2 activity
Moderate alcohol consumption and lipoprotein-associated phospholipase A2 activity
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DOI：
10.1016/j.numecd.2007.07.002
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发表时间：
2008-10-01
影响因子：
3.9
通讯作者：
Hendriks, Henk F. J.
中科院分区：
文献类型：
--
作者：
Beulens, Joline W. J.;van den Berg, Robin;Hendriks, Henk F. J.
背景和目的：研究适度饮酒对脂蛋白相关磷脂酶A2活性、炎症和氧化应激标志物的影响，以及这些影响是否会被BMI改变。方法与结果：11名瘦男性（BMI: 18.5-25 kg/m(2)）和9名超重男性（BMI: > - 27 kg/m(2)）参加了一项随机对照交叉试验。在连续3周每天饮用3罐啤酒（含40克乙醇）或无酒精啤酒后，采集空腹血液样本。与不含酒精的啤酒相比，啤酒后高密度脂蛋白胆固醇增加了18.2% (p < 0.001)，而低密度脂蛋白胆固醇下降了7.8% （p = 0.008）。在啤酒（47.5 +/- 0.8）和无酒精啤酒（48.9 +/- 0.8）之间，脂蛋白相关磷脂酶A2活性没有差异（p = 0.23）。高敏c反应蛋白未受影响，但与不含酒精的啤酒（96.9 +/- 6.5）相比，啤酒（114.0 +/- 6.9）后尿异前列腺素倾向于增加（p = 0.09）。观察到BMI和肝酶治疗之间的相互作用（p < 0.05），表明只有超重男性在适度饮酒后肝酶增加。结论：尽管对HDL和LDL胆固醇有深远的影响，但适度饮酒并不影响脂蛋白相关磷脂酶A2的活性。只有超重男性在饮酒后肝酶增加，这表明超重人群对适度饮酒的反应不太有利。(C) 2007年Elsevier B.V.出版
Background and aims: To investigate the effect of moderate alcohol consumption on lipoprotein-associated phospholipase A2 activity, markers of inflammation and oxidative stress and whether these effects are modified by BMI.Methods and results: Eleven lean (BMI: 18.5-25 kg/m(2)) and 9 overweight (BMI > 27 kg/m(2)) men participated in a randomized controlled crossover trial. After consuming 3 cans of beer (40 g ethanol) or alcohol-free beer daily during 3 weeks, fasting blood samples were taken. HDL cholesterol increased by 18.2% (p < 0.001) after beer compared to alcohol-free beer, while LDL cholesterol decreased by 7.8% (p = 0.008). Lipoprotein-associated phospholipase A2 activity was not different (p = 0.23) between beer (47.5 +/- 0.8) and alcohol-free beer (48.9 +/- 0.8). High-sensitive C-reactive protein was unaffected, but urinary isoprostanes tended to increase (p = 0.09) after beer (114.0 +/- 6.9) compared to alcohol-free beer (96.9 +/- 6.5). An interaction between BMI and treatment (p < 0.05) on liver enzymes was observed, indicating an increase of liver enzymes after moderate alcohol consumption in overweight men only.Conclusion: Despite profound effects on HDL and LDL cholesterol, moderate alcohol consumption did not affect lipoprotein-associated phospholipase A2 activity. Liver enzymes increased after alcohol consumption in overweight men only, suggesting a Less favorable response to moderate alcohol consumption in overweight people. (C) 2007 Published by Elsevier B.V.