Life history, immune function, and intestinal helminths: Trade-offs among immunoglobulin E, C-reactive protein, and growth in an Amazonian population.
Life history, immune function, and intestinal helminths: Trade-offs among immunoglobulin E, C-reactive protein, and growth in an Amazonian population.
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DOI：
10.1002/ajhb.21092
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发表时间：
2010-11
期刊：
影响因子：
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通讯作者：
Sugiyama LS
中科院分区：
文献类型：
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作者：
Blackwell AD;Snodgrass JJ;Madimenos FC;Sugiyama LS
蠕虫感染与宿主免疫力的变化有关，包括免疫球蛋白E（IgE）的产生增加和炎症减少。鉴于有限的能源预算，这些转变可能涉及能源分配的变化，以满足竞争性需求。在这里，我们测试生长，IgE和炎症标志物C反应蛋白（CRP）之间的潜在权衡。从厄瓜多尔东南部一个村庄的162名Shuar狩猎园艺家那里收集了干血斑和人体测量数据。酶联免疫吸附试验（ELISA）用于测量IgE和CRP。在三组中检查了IgE、CRP和人体测量学之间的关系：2-7岁儿童（n = 63）、8-15岁儿童（n = 61）和18岁以上成人（n = 37）。几何平均IgE为1，196 IU ml−1，几何平均CRP为1.33 mg l−1。在儿童中，IgE和CRP呈负相关（r =-0.21，P = 0.02，df = 122）。控制脂肪储存和年龄，IgE与儿童（t =-2.04，P = 0.04，df = 109）和成人（t =-3.29，P < 0.01，df = 33）的身材矮小相关。在儿童中，年龄和CRP之间存在显著的相互作用，例如，在年龄较小的儿童中，CRP与较矮的身材相关，但在年龄较大的儿童中，CRP与较高的身材相关（t = 2.15，P = 0.04，df = 109）。这些结果表明，蠕虫感染可能有与免疫学变化相关的隐藏成本，这些成本可能最终影响生长和其他生活史参数。
Infection with helminths is associated with shifts in host immunity, including increased production of immunoglobulin E (IgE) and reduced inflammation. Given limited energy budgets, these shifts may involve changes in energy allocation toward competing demands. Here we test for potential trade-offs between growth, IgE, and the inflammatory marker C-reactive protein (CRP). Dried blood spots and anthropometrics were collected from 162 Shuar forager-horticulturalists from a village in southeastern Ecuador. Enzyme-linked immunosorbent assays (ELISAs) were used to measure IgE and CRP. Relationships among IgE, CRP, and anthropometrics were examined in three groups: children aged 2–7 years (n = 63), children aged 8–15 (n = 61), and adults over age 18 (n = 37). Geometric mean IgE was 1,196 IU ml−1 while geometric mean CRP was 1.33 mg l−1. In children, IgE and CRP were negatively correlated (r = −0.21, P = 0.02, df = 122). Controlling for fat stores and age, IgE was associated with lower stature in children (t = −2.04, P = 0.04, df = 109), and adults (t = −3.29, P < 0.01, df = 33). In children there was a significant interaction between age and CRP, such that in younger children CRP was associated with shorter stature, but in older children was associated with greater stature (t = 2.15, P = 0.04, df = 109). These results suggest that infection with helminths may have hidden costs associated with immunological changes, and that these costs may ultimately affect growth and other life history parameters.