Innervation of bone marrow in the rabbit.
Innervation of bone marrow in the rabbit.
复制标题
兔子骨髓的神经支配。
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
R. McCuskey
中科院分区：
文献类型：
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作者：
M. Miller;R. McCuskey
采用组织化学方法对胎兔、新生兔和成年新西兰白化兔的胫骨进行研究，以阐明骨髓腔内血管和软组织神经支配的发育情况。
The tibias of fetal, neonatal and mature New Zealand albino rabbits were investigated histochemically to elucidate the development of innervation of the blood vessels and parenchyma in the marrow cavity.
The neurovascular complex in the marrow was developed poorly at birth. Adrenergic nerves were detected with difficulty and accompanied thin walled blood vessels which could not be identified as either arterial or venous. Large bundles of nerves, suggesting the beginning of myelination, appeared by the 5th neonatal day. Simultaneously, several other morphological changes occurred. Arteries in the marrow developed a PAS positive adventitia which loosely held the nerve bundles; complete internal elastic lamellae and muscular medias also were seen for the first time. Concomitantly, there was incrcease in sulfated acid mucopolysaccharides in the connective tissue of the developing marrow cavity and large numbers of osteoclasts were seen in the enlarging marrow cavity. At this time scattered foci of early haemopoietic activity were found.
In the adult, adrenergic and cholinesterase positive nerves were distributed along both arteries and veins. Adrenergic fibers also were present on arterioles and on thin walled vessels (sinusoids and venules). Among the parenchyma, cholinesterase positive fibers were found more frequently than were adrenergic fibers. While some of the fibers were observed near haemopoietic foci and fat cells, no specific terminations were observed. The ratio of fibers to cellular elements in the marrow did not seem to differ with the degree of haemopoietic activity.
The results suggest that the development of a mature neurovascular complex is critical to the establishment of microenvironment suitable for haemopoiesis to occur. In addition, the reported neural influence on haemopoiesis is suggested to be mediated through vasomotor activity.