Chronic arm morbidity after curative breast cancer treatment: Prevalence and impact on quality of life
Chronic arm morbidity after curative breast cancer treatment: Prevalence and impact on quality of life
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DOI：
10.1200/jco.2002.09.018
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发表时间：
2002-10-15
影响因子：
45.3
通讯作者：
Olivotto, IA
中科院分区：
文献类型：
--
作者：
Kwan, W;Jackson, J;Olivotto, IA
目的：为了确定的患病率和慢性手臂发病率的影响因素，包括在乳腺癌患者治疗后水肿，并评估手臂发病率对生活质量（QOL）的影响。患者和方法：开发了一个四个问题的筛选问卷，并邮寄给一个随机样本的744例乳腺癌患者在两个癌症治疗中心，从1993年至1997年治愈。患者没有复发，并且从诊断开始至少2年。根据调查结果，将受访者分为有或没有手臂相关症状。然后邀请每组的分层随机样本对他们的症状和体征进行详细评估，包括是否存在水肿。他们的生活质量进行了评估，由欧洲组织的研究和治疗癌症的生活质量问卷C-30和一个详细的手臂问题问卷，评估日常手臂functioning.Results的各个方面：大约一半的所有筛选的患者有症状和12.5%的所有评估患者有水肿。腋窝淋巴结清扫（AD）和清扫后腋窝放疗（RT）与手臂症状的发生有统计学意义（AD的比值比= 3.3，P
Purpose : To determine the prevalence of and contributing factors for chronic arm morbidity including lymphedema in breast cancer patients after treatment and to assess the impact of arm morbidity on quality of life (QOL).Patients and Methods: A four-question screening questionnaire was developed and mailed to a random sample of 744 breast cancer patients treated curatively in two cancer centers from 1993 to 1997. Patients were without recurrence and at least 2 years from diagnosis. Respondents were classified as with or without arm-related symptoms on the basis of the survey. Stratified random samples from each group were then invited for a detailed assessment of their symptoms and signs, including the presence of lymphedema. Their QOL was assessed by the European Organization for Research and Treatment of Cancer QOL Questionnaire C-30 and by a detailed arm problem questionnaire that assessed various aspects of daily arm functioning.Results: Approximately half of all screened patients were symptomatic and 12.5% of all assessed patients had lymphedema. Axillary dissection (AD) and axillary radiotherapy (RT) after dissection were statistically significantly related to the occurrence of arm symptoms (odds ratio for AD = 3.3, P