Sleep disturbances and nocturnal symptoms: relationships with quality of life in a population-based sample of women with interstitial cystitis/bladder pain syndrome.
Sleep disturbances and nocturnal symptoms: relationships with quality of life in a population-based sample of women with interstitial cystitis/bladder pain syndrome.
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DOI：
10.5664/jcsm.4292
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发表时间：
2014-12
期刊：
影响因子：
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通讯作者：
W. Troxel;M. Booth;Daniel J Buysse;M. Elliott;A. Suskind;J. Q. Clemens;S. Berry
中科院分区：
文献类型：
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作者：
W. Troxel;M. Booth;Daniel J Buysse;M. Elliott;A. Suskind;J. Q. Clemens;S. Berry
研究目的描述间质性膀胱炎/膀胱疼痛综合征（IC/BPS）女性患者睡眠障碍的性质及其对生活质量（QOL）的影响。参与者是来自电话概率调查的3，397名符合IC/BPS症状标准的女性。睡眠质量、持续时间和IC/BPS夜间症状（即，由于膀胱疼痛、尿急或需要使用浴室而导致的睡眠困难）、一般QOL（精神和身体健康以及性功能）和IC/BPS QOL损害通过电话访谈期间的自我报告进行评估。结果超过一半的被调查者报告睡眠质量差，睡眠时间≤ 6小时，或因IC/BPS症状而睡眠困难。在协变量调整后，睡眠时间短与IC/BPS QOL损害较大（β =-0.04; p <0.001）和自我报告的身体健康状况较差（β = 1.86; p <0.001）显著相关。睡眠质量差与IC/BPS QOL受损程度更大（β = 0.06; p <0.001）、自我报告的身体健康状况更差（β =-2.86; p <0.001）和性功能障碍更严重（β =-0.04; p <0.05）显著相关。经协变量校正后，IC/BPS夜间症状与IC/BPS受损程度更大（β = 0.14; p <0.001）、身体健康状况更差（β =-2.76; p <0.001）和心理健康状况更差（β = 0.52; p <0.01）以及性功能障碍程度更大（β =-0.10; p <0.001）显著相关。在进一步校正IC/BPS夜间症状后，我们发现睡眠质量差和睡眠时间短是自我报告的身体健康状况差的独立相关因素。结论：睡眠质量差和睡眠时间短，以及疾病特异性睡眠障碍，在IC/BPS女性中非常普遍，并与疾病特异性和总体QOL较差相关。
STUDY OBJECTIVES To characterize the nature and impact of sleep disturbances on quality of life (QOL) in women with interstitial cystitis/bladder pain syndrome (IC/BPS). METHODS Participants were 3,397 women from a telephone probability survey who met IC/BPS symptom criteria. Sleep quality, duration, and IC/BPS nocturnal symptoms (i.e., trouble sleeping due to bladder pain, urgency, or needing to use the bathroom), general QOL (mental and physical health and sexual functioning), and IC/BPS QOL impairment were assessed via self-report during telephone interview. RESULTS Over half of the sample reported poor sleep quality, sleep duration ≤ 6 hours, or trouble sleeping due to IC/BPS symptoms. After covariate adjustment, short sleep duration was significantly associated with greater IC/BPS QOL impairment (β = -0.04; p < 0.001) and poorer self-reported physical health (β = 1.86; p < 0.001). Poor sleep quality was significantly associated with greater IC/BPS QOL impairment (β = 0.06; p < 0.001), poorer self-reported physical health (β = -2.86; p < 0.001), and greater sexual dysfunction (β = -0.04; p < 0.05). IC/BPS nocturnal symptoms were significantly associated with greater IC/BPS impairment (β = 0.14; p < 0.001), poorer physical health (β = -2.76; p < 0.001) and mental health (β = 0.52; p < 0.01), and greater sexual dysfunction (β = -0.10; p < 0.001), after covariate adjustment. After further adjustment for IC/BPS nocturnal symptoms, we found that poor sleep quality and short sleep duration were independent correlates of poor self-reported physical health. CONCLUSIONS Poor sleep quality and short sleep duration, as well as disorder-specific sleep disturbances, are highly prevalent in women with IC/BPS and are associated with poorer disease-specific and general QOL.