Hypersensitivity reaction associated with phenytoin.
Hypersensitivity reaction associated with phenytoin.
复制标题
DOI：
10.4103/0976-0105.168054
复制
发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Basutkar RS
中科院分区：
文献类型：
--
作者：
Indu TH;Basutkar RS
抗癫痫药物（AED）的超敏反应通常与芳香族AED有关。我们提出的情况下，过敏反应，其次是苯妥英钠与地西泮和雷尼替丁在全身强直阵挛性癫痫发作的患者管理。抗原抗体反应或环氧化物水解酶水平降低是众所周知的苯妥英。文献中还报告了由于与地西泮联合给药时的竞争性抑制导致血清苯妥英水平升高而引起毒性。预防AED的不良反应是一个多阶段的过程，需要通过仔细监测和及时干预来实施预防措施。
Hypersensitivity reactions with antiepileptic drugs (AEDs) are generally associated with aromatic AEDs. We present a case of hypersensitivity reactions followed by administration of phenytoin with diazepam and ranitidine in a patient with generalized tonic-clonic seizures. Antigen-antibody reactions or decreased levels of epoxide hydrolase are well known with phenytoin. Increased level of serum phenytoin causing toxicities due to competitive inhibition with diazepam on co-administration was also reported in the literature. Prevention of the adverse effects with AEDs is a multi-stage process, which requires implementation of preventive measures through careful monitoring and prompts interventions.