Rapid progression of rhabdoid components of a composite high-grade glioma and rhabdoid tumor in the occipital lobe of an adult
Rapid progression of rhabdoid components of a composite high-grade glioma and rhabdoid tumor in the occipital lobe of an adult
复制标题
成人枕叶复合性高级别胶质瘤和横纹肌样瘤的横纹肌样成分快速进展
DOI：
10.1007/s10014-011-0069-6
复制
发表时间：
2012
影响因子：
3.3
通讯作者：
Nishizawa S.
中科院分区：
文献类型：
--
作者：
Yamamoto J;Takahashi M;Nakano Y;Soejima Y;Saito T;Akiba D;Hirato J;Nakazato Y;Nishizawa S.
我们报告一个非常罕见的病例复合高度胶质瘤和横纹肌样瘤在一个成年人。一位22岁的女性，在右侧枕叶出现实体瘤伴周围脑水肿的闪烁性暗瘤。肿瘤被大面积切除。组织学检查显示肿瘤主要由ini1阳性的高级别胶质瘤组织组成，其中含有ini1阴性的横纹肌成分。她接受了放疗和化疗。术后3个月，患者再次主诉视力障碍，肿瘤在切除腔内复发。进行了第二次手术。第二次手术标本的组织学检查结果与第一次手术标本的组织学检查结果完全不同。只有横纹肌成分增殖显著，不表达INI1。沿颅脊髓轴弥漫性播散最终进展，患者在初步诊断后5个月死亡。我们认为ini1基因的失活会影响细胞的增殖活性和对化疗和放疗的耐药性。
We report a very unusual case of a composite high-grade glioma and rhabdoid tumor in an adult. A 22-year-old woman presented with scintillating scotoma due to a solid tumor with surrounding brain edema in the right occipital lobe. The tumor was grossly resected. Histological examinations showed that the tumor was mainly composed of INI1-positive high-grade glioma tissue containing an INI1-negative rhabdoid component. She received radiation therapy and chemotherapy. Three months after the surgery, she again complained of visual disturbances, and tumor recurrence within the resection cavity was noted. A second operation was performed. The findings of histological examinations of the surgical specimen obtained during the second surgery were completely different from those of the specimen obtained during the initial surgery. Only the rhabdoid component showed remarkable proliferation and did not express INI1. Diffuse dissemination along the craniospinal axis eventually progressed, and she died 5 months after the initial diagnosis. We suggest that the inactivation of theINI1gene affects potent proliferation activity and resistance to both chemotherapy and radiation therapy.