Dynamic simulations of membranes with cytoskeletal interactions
Dynamic simulations of membranes with cytoskeletal interactions
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DOI：
10.1103/physreve.72.011910
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发表时间：
2005-07-01
影响因子：
2.4
通讯作者：
Brown, FLH
中科院分区：
文献类型：
--
作者：
Lin, LCL;Brown, FLH
描述了一种弹性膜片在长时间尺度上的动力学仿真算法。我们的模型考虑了膜和周围溶剂之间的隐式流体动力耦合，并允许作用在膜表面的任意外力。特别是，该方法非常适合于研究膜与细胞骨架细丝的相互作用。作为红细胞膜的模型，我们给出了附着在有规则网络的血影蛋白细丝上的脂质双层的热波动的结果。定量了血影蛋白网络上双分子层的动态涨落，并用来预测红血球表面带3的宏观扩散常数。我们发现，温度波动可能在红细胞膜平面上的带3的迁移率中起作用。
We describe a simulation algorithm for the dynamics of elastic membrane sheets over long length and time scales. Our model includes implicit hydrodynamic coupling between membrane and surrounding solvent and allows for arbitrary external forces acting on the membrane surface. In particular, the methodology is well suited to studying membranes in interaction with cytoskeletal filaments. We present results for the thermal undulations of a lipid bilayer attached to a regular network of spectrin filaments as a model for the red blood cell membrane. The dynamic fluctuations of the bilayer over the spectrin network are quantified and used to predict the macroscopic diffusion constant of band 3 on the surface of the red blood cell. We find that thermal undulations likely play a role in the mobility of band 3 in the plane of the erythrocyte membrane.