EARLY TRYPSIN ACTIVITY IS PART OF THE SIGNAL-TRANSDUCTION SYSTEM THAT ACTIVATES TRANSCRIPTION OF THE LATE TRYPSIN GENE IN THE MIDGUT OF THE MOSQUITO, AEDES-AEGYPTI
EARLY TRYPSIN ACTIVITY IS PART OF THE SIGNAL-TRANSDUCTION SYSTEM THAT ACTIVATES TRANSCRIPTION OF THE LATE TRYPSIN GENE IN THE MIDGUT OF THE MOSQUITO, AEDES-AEGYPTI
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DOI：
10.1016/0965-1748(94)00061-l
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发表时间：
1995-02-01
影响因子：
3.8
通讯作者：
WELLS, MA
中科院分区：
文献类型：
--
作者：
BARILLASMURY, CV;NORIEGA, FG;WELLS, MA
胰蛋白酶活性在第一个小时内喂养后是必不可少的诱导晚期胰蛋白酶基因的表达。这些结果与消化过程中释放的游离氨基酸或其他产物可能是晚期胰蛋白酶转录激活的初始信号的想法一致。除了早期胰蛋白酶外，还必须翻译一些其他因子以诱导晚期胰蛋白酶。这是消化酶的蛋白水解活性是调节第二基因表达的信号转导系统的一部分的第一种情况。两种胰蛋白酶的存在使蚊子能够评估膳食的质量，并以显着的灵活性调整特定膳食的晚期胰蛋白酶水平。
Trypsin activity during the first hours after feeding is essential to induce late trypsin gene expression. These results are consistent with the idea that free amino acids or other products released during digestion might be the initial signal for transcriptional activation of late trypsin. Besides early trypsin, some other factor(s) have to be translated for induction of late trypsin. This is the first case in which the proteolytic activity of a digestive enzyme is part of the signal transduction system which regulates expression of a second gene. The presence of two trypsins allows the mosquito to assess the quality of the meal and adjust the levels of late trypsin for a particular meal with remarkable flexibility.