Caffeine, coffee, and tea intake and urinary estrogens and estrogen metabolites in premenopausal women.
Caffeine, coffee, and tea intake and urinary estrogens and estrogen metabolites in premenopausal women.
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绝经前妇女中的咖啡因，咖啡和茶的摄入量以及尿雌激素和雌激素代谢产物。
DOI：
10.1158/1055-9965.epi-15-0246
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发表时间：
2015-08
期刊：
影响因子：
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通讯作者：
Eliassen AH
中科院分区：
文献类型：
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作者：
Sisti JS;Hankinson SE;Caporaso NE;Gu F;Tamimi RM;Rosner B;Xu X;Ziegler R;Eliassen AH
先前的研究发现，乳腺癌与咖啡因和咖啡摄入量之间存在微弱的负相关，可能是通过它们对性激素的影响来介导的。采用高效液相色谱/串联质谱法对587名绝经前妇女的15种雌激素和雌激素代谢物（EM）水平进行定量分析，这些妇女参加了护士健康研究II，并从自我报告的食物频率问卷中获取了黄体中期尿液样本和咖啡因、咖啡和/或茶摄入量。使用多变量线性混合模型估计个体EM的几何平均值、摄入类别的途径和比率，以及线性趋势检验的P值。与咖啡因摄入量最低四分位数的女性相比，咖啡因摄入量最高四分位数的女性尿中16α-羟基雌酮（差异28%; P趋势=0.01）和16-表雌三醇（差异13%; P趋势=0.04）浓度较高，母体雌激素/2-、4-、16-途径比值降低（P趋势=0.03）。咖啡摄入量与较高的2-儿茶酚相关，包括2-羟基雌酮（57%的差异，≥4杯/天vs. ≤6杯/周; P趋势=0.001）和2-羟基雌酮（52%的差异; P趋势=0.001），以及几个比率指标。脱咖啡因咖啡与2-途径代谢无关，但摄入量最高（与最低）类别（≥2杯/天与≤1-3杯/月）的女性的两种16-途径代谢物雌三醇（25%差异; P趋势=0.01）和17-表雌三醇（48%差异; P趋势=0.0004）水平显著较低。茶摄入量与17-表雌三醇呈正相关（52%差异; P趋势=0.01）。咖啡因和咖啡摄入量都与绝经前妇女的雌激素代谢有关。咖啡因和咖啡的消费可能会改变绝经前雌激素代谢的模式。
Prior studies have found weak inverse associations between breast cancer and caffeine and coffee intake, possibly mediated through their effects on sex hormones. High-performance liquid chromatography/tandem mass spectrometry was used to quantify levels of 15 individual estrogens and estrogen metabolites (EM) among 587 premenopausal women in the Nurses’ Health Study II with mid-luteal phase urine samples and caffeine, coffee and/or tea intakes from self-reported food frequency questionnaires. Multivariate linear mixed models were used to estimate geometric means of individual EM, pathways and ratios by intake categories, and P-values for tests of linear trend. Compared to women in the lowest quartile of caffeine consumption, those in the top quartile had higher urinary concentrations of 16α-hydroxyestrone (28% difference; P-trend=0.01) and 16-epiestriol (13% difference; P-trend=0.04), and a decreased parent estrogens/2-, 4-, 16-pathway ratio (P-trend=0.03). Coffee intake was associated with higher 2-catechols, including 2-hydroxyestradiol (57% difference, ≥4 cups/day vs. ≤6 cups/week; P-trend=0.001) and 2-hydroxyestrone (52% difference; P-trend=0.001), and several ratio measures. Decaffeinated coffee was not associated with 2-pathway metabolism, but women in the highest (vs. lowest) category of intake (≥2 cups/day vs. ≤1–3 cups/month) had significantly lower levels of two 16-pathway metabolites, estriol (25% difference; P-trend=0.01) and 17-epiestriol (48% difference; Ptrend=0.0004). Tea intake was positively associated with 17-epiestriol (52% difference; Ptrend=0.01). Caffeine and coffee intake were both associated with profiles of estrogen metabolism in premenopausal women. Consumption of caffeine and coffee may alter patterns of premenopausal estrogen metabolism.