Effect of local hyperthermia on metastases in oral squamous cell carcinoma
Effect of local hyperthermia on metastases in oral squamous cell carcinoma
复制标题
DOI：
10.1054/ijom.2001.0176
复制
发表时间：
2002-02-01
影响因子：
2.4
通讯作者：
Hoshina, H
中科院分区：
文献类型：
--
作者：
Nagashima, K;Takagi, R;Hoshina, H
在这项实验研究中，患有口腔鳞状细胞癌(O-1N)的仓鼠接受了局部热疗。口腔鳞状细胞癌具有很高的淋巴结转移潜力。从病理角度观察热疗对区域淋巴结转移的影响。O-1N加热两次，每次包括射频电容式加热(13.56 MHz)，在43℃下加热40分钟。分别于加热后14、17、21、28天摘除颈部淋巴结，并进行组织学检查。假手术组和对照组的仓鼠在同一天被处死，并以相同的方式检查标本。热疗组的淋巴结转移率(36.4%)明显低于假手术组(68.5%)和对照组(65.0%)(P=0.02)。假手术组和对照组的淋巴结转移模式均较热疗组明显提前。多因素分析显示，热疗后未发现肿瘤的金黄地鼠淋巴结转移率很低(7.7%)。热疗与抑制颈淋巴转移相关(P=0.02)。我们的研究结果表明，当原发肿瘤对治疗有组织学反应时，局部热疗可抑制淋巴转移。
In this experimental study, hamsters with oral squamous cell carcinoma (O-1N), which has a high potential for lymph node metastasis, received treatment with local hyperthermia. The effect of hyperthermia on regional lymph node metastases was examined pathologically. O-1N was heated twice, each session consisting of radiofrequency capacitive heating (13.56 MHz) for 40 min at 43degreesC. Cervical lymph nodes were excised 14, 17, 21, and 28 days after heating and were examined histologically. Hamsters in the sham and control groups were killed oil the same days and specimens were examined in a same manner. The incidence of lymph node metastasis was significantly lower in the hyperthermia group (36.4%) than in the sham 68.5%) and control (65.0%) groups (both P=0.02). The patterns of lymph node metastasis in the sham and control groups were more advanced than that in the hyperthermia group. The incidence of lymph node metastasis was very low (7.7%) in hamsters with no evidence Of tumour after hyperthermia, On multivariate analysis. hyperthermia correlated with inhibition of cervical lymph node metastasis (P=0.02). Our findings suggest that local hyperthermia inhibits lymph node metastasis when the primary tumour responds histologically to treatment.