Breed-associated variability in serum biochemical analytes in four large-breed dogs.
Breed-associated variability in serum biochemical analytes in four large-breed dogs.
复制标题
四只大型犬的血清生化分析物与品种相关的变异性。
DOI：
10.1111/j.1939-165x.2009.00134.x
复制
发表时间：
2009
影响因子：
1.2
通讯作者：
C. Munoz
中科院分区：
文献类型：
--
作者：
L. Sharkey;Karen Gjevre;Rebecca L. Hegstad;S. Torres;C. Munoz
背景
遗传背景可以影响家畜物种的血液学和血清生化分析物的预期值。
目标
本研究的目的是确定 4 个品种的健康纯种狗的血清生化变量是否存在与品种相关的差异，并制定适当的参考区间。
方法
该研究包括阿拉斯加雪橇犬 (n=59)、西伯利亚哈士奇犬 (n=78)、金毛寻回犬 (n=90) 和英国塞特犬 (n=77)。这些狗的平均年龄为 42 个月（范围 10-112 个月），每个品种都包含未绝育和绝育的雌雄狗。进行血清生化分析（Olympus AU400e）以及体检、全血细胞计数和尿液分析，以确保狗的临床健康状况。以非参数方式评估生化分析值的差异，并计算所有品种组合的参考区间作为中心 95% 百分位。
结果
除碱性磷酸酶、葡萄糖和氯化物外，所有血清生化分析物在品种之间均观察到显着差异。不同品种之间的分析物范围有很大程度的重叠。
结论
尽管观察到血清生化值有许多统计学上显着的品种相关差异，但差异很小，不太可能具有临床相关性或影响医疗决策。
BACKGROUND
Genetic background can influence the expected values of hematologic and serum biochemical analytes in domestic animal species.
OBJECTIVE
The purpose of this study was to determine if there are breed-related differences in serum biochemical variables in healthy purebred dogs of 4 breeds and to develop appropriate reference intervals.
METHODS
Alaskan Malamutes (n=59), Siberian Huskies (n=78), Golden Retrievers (n=90), and English Setters (n=77) were included in the study. The dogs had a median age of 42 months (range 10-112 months) and each breed included a mix of intact and neutered dogs of both sexes. Serum biochemical profiles (Olympus AU400e) were performed along with physical examinations, CBCs, and urinalyses to ensure dogs were clinically healthy. Differences in the values of biochemical analytes were assessed nonparametrically and reference intervals for all breeds combined were calculated as the central 95% percentile.
RESULTS
Significant differences were observed between breeds for all serum biochemical analytes except alkaline phosphatase, glucose, and chloride. The analyte ranges had a large degree of overlap between the different breeds.
CONCLUSIONS
Although many statistically significant breed-related differences in serum biochemical values were observed, the differences were small and unlikely to have clinical relevance or impact medical decision making.