Brain functional and effective connectivity underlying the information processing speed assessed by the Symbol Digit Modalities Test
Brain functional and effective connectivity underlying the information processing speed assessed by the Symbol Digit Modalities Test
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DOI：
10.1016/j.neuroimage.2018.09.080
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发表时间：
2019-01-01
期刊：
影响因子：
5.7
通讯作者：
Leoni, R. F.
中科院分区：
文献类型：
--
作者：
Silva, P. H. R.;Spedo, C. T.;Leoni, R. F.
延迟信息处理速度（IPS）通常是注意力缺陷的基础，在创伤性脑损伤、帕金森病、抑郁症、痴呆和多发性硬化症患者中尤为明显。因此，确定负责这种基本认知功能的大脑网络，以了解IPS缺陷并制定有效的康复计划是很有意义的。我们评估了大脑功能连通性和有效连通性在一个改编版本的符号数字模式测试的表现。采用动态因果模型，建立了健康受试者IPS功能的网络模型。16名右撇子志愿者（7名女性，年龄：29.7 +/- 5.0岁）在书面同意参与后被纳入研究。在3T扫描仪上获得功能磁共振图像。根据我们的研究结果，两个系统在IPS任务执行过程中相互作用。一个是由额顶叶和额枕叶网络组成的，与控制目标导向（自上而下）的刺激和反应选择有关，而第二个是由颞顶叶和下额叶皮层组成的，与大脑中刺激驱动的注意力有关。此外，默认模式网络与与任务正相关的网络（主要是与视觉检测和加工相关的网络）存在显著相关，表明其在涉及IPS的功能整合中具有相关作用。因此，通过一种方法提出了ips相关网络，该方法可能对考虑其他认知功能和任务、临床组和纵向评估的未来研究有用。
Delayed Information Processing Speed (IPS) often underlies attention deficits and is particularly evident in patients with traumatic brain injury, Parkinson's disease, depression, dementia, and multiple sclerosis. Therefore, it is of interest to determine the brain network that is responsible for such essential cognitive function to understand IPS deficits and to develop effective rehabilitation programs. We assessed brain functional connectivity and effective connectivity during the performance of an adapted version of the Symbol Digit Modalities Test. Using dynamic causal modeling, we focused on obtaining a network model for IPS function in healthy subjects. Sixteen right-handed volunteers (seven women, age: 29.7 +/- 5.0 years) were included in the study after giving written consent for participating. Functional magnetic resonance images were acquired in a 3T scanner. According to our results, two systems interact during the IPS task performance. One is formed by frontoparietal and fronto-occipital networks, related to the control of goal-directed (top-down) selection for stimuli and response, while the second is composed of the temporoparietal and inferior frontal cortices, which are associated with stimulus-driven attention in the brain. Additionally, the default-mode network showed a significant correlation with networks positively associated with the task, mainly those related to visual detection and processing, indicating its relevant role in functional integration involving IPS. Therefore, an IPS-related network was proposed through a methodology that may be useful for future studies considering other cognitive functions and tasks, clinical groups, and longitudinal assessments.