Interleukin-12. Biologic activity, therapeutic utility, and role in disease.
Interleukin-12. Biologic activity, therapeutic utility, and role in disease.
复制标题
白介素-12。
DOI：
--
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Brunda Mj
中科院分区：
文献类型：
--
作者：
Hendrzak Ja;Brunda Mj
IL-12是一种异二聚体细胞因子，通过对T细胞和NK细胞的调节作用促进细胞介导的免疫。在一些小鼠传染病模型中，IL-12被证明是内源性产生的，以应对感染，并且外源性给予IL-12给患有传染病或肿瘤的小鼠都产生了显着的治疗效果。IL-12在疾病过程的早期具有保护作用，对已建立的疾病也有保护作用。然而，在宿主对这些传染病和恶性肿瘤的反应中有益的IL-12的生物活性在某些疾病状态下也可能是有害的。因此，如果在适当的条件下使用，IL-12在治疗各种人类疾病方面具有相当大的潜力。同样，IL-12拮抗剂可能在控制通过免疫机制介导的病理疾病中发挥作用。
Abstract IL-12 is a heterodimeric cytokine that promotes cell-mediated immunity through its regulatory effects on T and NK cells. In some murine infectious disease models, IL-12 was shown to be produced endogenously in response to infection, and the exogenous administration of IL-12 to mice with either infectious diseases or tumors has resulted in significant therapeutic effects. IL-12 was protective early in the disease process, as well as against established disease. However, the biologic activities of IL-12 that are beneficial in the host response to these infectious diseases and malignancies can also be deleterious in certain disease states. Thus, IL-12 has considerable potential for the treatment of a variety of human disorders if used under the appropriate conditions. Likewise, antagonists of IL-12 may have a role in controlling diseases with pathologies that are mediated through immune mechanisms.