The intestinal microvasculature as a therapeutic target in inflammatory bowel disease
The intestinal microvasculature as a therapeutic target in inflammatory bowel disease
复制标题
DOI：
10.1196/annals.1326.003
复制
发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Binion, David G.
中科院分区：
文献类型：
--
作者：
Hatoum, Ossama A.;Heidemann, Jan;Binion, David G.
慢性炎症是一个复杂的生物过程，涉及免疫细胞和非免疫细胞，包括微脉管系统及其内皮细胞。越来越多的证据表明，微血管系统在炎症性肠病（IBD；克罗恩病和溃疡性结肠炎）的病理生理学中发挥着不可或缺的作用。微脉管系统通过白细胞募集改变、灌注受损和血管生成导致组织重塑而导致慢性炎症。 IBD 微血管生物学的这些不同领域代表了目前正在研究的治疗靶点。
Chronic inflammation is a complex biologic process which involves immune as well as non-immune cells including the microvasculature and its endothelial lining. Growing evidence suggests that the microvasculature plays an integral role in the pathophysiology of inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis). The microvasculature contributes to chronic inflammation through altered leukocyte recruitment, impaired perfusion, and angiogenesis leading to tissue remodeling. These diverse areas of IBD microvascular biology represent therapeutic targets that are currently undergoing investigation.