Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer
Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer
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DOI：
10.1016/s0304-3835(02)00460-3
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发表时间：
2002-12-15
期刊：
影响因子：
9.7
通讯作者：
Griffiths, LR
中科院分区：
文献类型：
--
作者：
Curran, JE;Weinstein, SR;Griffiths, LR
核因子-kappaB(NF-kappaB)是一种转录因子，负责调节多种参与细胞增殖、分化、凋亡和转移的基因的表达。核因子-kappaB与IkappaB抑制蛋白相互作用，调节基因表达。这项研究调查了与散发性乳腺癌有关的NF-kappaB和IkappaB、NFKB1和NFKBIA基因编码的常见变异。在乳腺癌患者和年龄匹配的对照人群中进行了基因分型。结果不支持被测试的NFKB1和NFKBIA多态与被测试的高加索人群中散发性乳腺癌的易感性有关。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
Nuclear factor kappa-beta (NF-kappaB) is a transcription factor responsible for modulating the expression of many genes involved in cell proliferation, differentiation, apoptosis and metastasis. NF-kappaB interacts with IkappaB inhibitory proteins to regulate,gene expression. This study investigated common variants within the genes coding for NF-kappaB and IkappaB, NFKB1 and NFKBIA, for involvement in sporadic breast cancer. Genotypes were determined in a population of breast cancer affected individuals and age-matched controls. Results do not support an involvement of the tested NFKB1 and NFKBIA polymorphisms in susceptibility to sporadic breast cancer, in the tested Caucasian population. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.